ArticleClinical and experimental immunology2001
Neutrophil accumulation induced by bacterial lipopolysaccharide: effects of dexamethasone and annexin 1.
Article in Clinical and experimental immunology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 65 citations in OpenAlex.
- Trial
- Activated carbon ameliorates type 2 diabetes via metabolic remodeling of the gut microbiota.Microbiology spectrum · 2025Article
- Factors associated with a reduction in the preventive effect of intravenous dexamethasone on rebound pain after axillary brachial plexus block.British journal of anaesthesia · 2025Observational
- Assessment of Lactobacillus rhamnosus mediated protection against arsenic-induced toxicity in zebrafish: a qPCR-based analysis of Firmicutes and Bacteroidetes groups and embryonic development.Archives of microbiology · 2023Article
- The modulation of gut microbiota by herbal medicine to alleviate diabetic kidney disease - A review.Frontiers in pharmacology · 2022Review
- Role of gut microbiota in the pathogenesis and treatment of diabetes mullites: Advanced research-based review.Frontiers in microbiology · 2022Review
- Review
- Focus on the Gut-Kidney Axis in Health and Disease.Frontiers in medicine · 2020Review
- The role of gut microbiome and its interaction with arsenic exposure in carotid intima-media thickness in a Bangladesh population.Environment international · 2019Article
- The impact of hydrocortisone treatment on neutrophil gelatinase-associated lipocalin release in porcine endotoxemic shock.Intensive care medicine experimental · 2017Article
- Exposure to inorganic arsenic can lead to gut microbe perturbations and hepatocellular carcinoma.Acta pharmaceutica Sinica. B · 2016Review
- Arsenic induces structural and compositional colonic microbiome change and promotes host nitrogen and amino acid metabolism.Toxicology and applied pharmacology · 2015Article
- A novel anti-histone H1 monoclonal antibody, SSV monoclonal antibody, improves lung injury and survival in a mouse model of lipopolysaccharide-induced sepsis-like syndrome.BioMed research international · 2015Article
- Role and interactions of annexin A1 and oestrogens in the manifestation of sexual dimorphisms in cerebral and systemic inflammation.British journal of pharmacology · 2013Article
- Angiopoietin-1 variant reduces LPS-induced microvascular dysfunction in a murine model of sepsis.Critical care (London, England) · 2012Article
- Mast cells modulate the inflammatory process in endotoxin-induced uveitis.Molecular vision · 2011Article
- Antiallergic cromones inhibit neutrophil recruitment onto vascular endothelium via annexin-A1 mobilization.Arteriosclerosis, thrombosis, and vascular biology · 2010Article
- Gut microbiota in human adults with type 2 diabetes differs from non-diabetic adults.PloS one · 2010Article
- Independent roles of macrophage migration inhibitory factor and endogenous, but not exogenous glucocorticoids in regulating leukocyte trafficking.Microcirculation (New York, N.Y. : 1994) · 2009Article
- Annexin-A1: a pivotal regulator of the innate and adaptive immune systems.British journal of pharmacology · 2008Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Annexin 1 (ANX-1) can reduce leucocyte migration in response to cytokines and chemokines in some rodent models of inflammation. However, its effectiveness against an inflammatory stimulus as strong as bacterial lipopolysaccharide (LPS) is unknown. Thus, we have examined whether ANX-1 can modulate LPS-induced neutrophil accumulation in the rat, as assessed by intravital microscopy and by myeloperoxidase (MPO) assay. The anti-inflammatory glucocorticoid, dexamethasone (DEX) was also studied for comparison. LPS superfusion induced adhesion of leucocytes to the endothelium and a subsequent increase in emigration from rat post-capillary venules over 2 h as assessed by intravital microscopy. Either ANX-1 or DEX was able to attenuate this adhesion and emigration of leucocytes. MPO activity in the lung, kidney and ileum was elevated after a 6-h exposure to LPS (intraperitoneal), indicating accumulation of neutrophils in these tissues. DEX attenuated the LPS-induced increase in MPO in the ileum but had no effect on MPO in the lungs or kidneys. This would suggest that the underlying mechanism by which neutrophils accumulate in the ileum, and more generally in the gastrointestinal compartment, is different from other vascular beds. ANX-1 had no effect on the LPS-induced increase in MPO activity in any of the tissues studied. Thus, from these data, ANX-1 appears to reduce leucocyte adhesion and emigration induced by a short-term (2 h), but not a longer (6 h) exposure to LPS.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.