ArticleMolecular cell2000
The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues.
Article in Molecular cell, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 630 papers.
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Who cites it
630 citing papers in PubMed, 1,468 citations in OpenAlex.
- Safety and efficacy of navitoclax, a BCL-2 and BCL-XLeukemia & lymphoma · 2021Trial
- The NLRP3 inflammasome at the crossroads of innate immune signaling and cell death.Cellular & molecular immunology · 2026Review
- Apoptosis inhibition reprograms alveolar myofibroblasts toward ductal myofibroblasts.Cell reports · 2026Article
- Apoptosis promotes fertility in Caenorhabditis elegans by maintaining functional germline morphology.Development (Cambridge, England) · 2026Article
- Targeting programmed cell death: a novel therapeutic paradigm for cancer based on mode-of-death classification.Apoptosis : an international journal on programmed cell death · 2026Review
- Relationship between different modes of death and premature ovarian insufficiency: a literature review.Apoptosis : an international journal on programmed cell death · 2026Review
- Surgical resection of longitudinal vaginal septum improves fertility and reproductive capacity in mice.Reproduction & fertility · 2026Article
- Extrinsic apoptosis and necroptosis in telencephalic development: a single-cell mass cytometry study.Cell death and differentiation · 2026Article
- Genome-wide reconstruction of the intrinsic apoptosis pathway in Haemonchus contortus.BMC genomics · 2026Article
- BAX as a Biomarker for Predicting Immunotherapeutic Efficacy in Uveal Melanoma Patients: A Comprehensive Analysis.Molecular biotechnology · 2026Article
- The interplay between circadian rhythm components and apoptosis in health and disease.Human cell · 2026Review
- Actomyosin contractility and a threshold of cadherin cell adhesion are required during tissue fusion.The Journal of cell biology · 2026Article
- Bcl-2 modifying factor (Bmf): "a mysterious stranger" in the Bcl-2 family proteins.Cell death and differentiation · 2026Review
- Loss of Frmd5 Inhibits Jak2-Stat3 Signalling Pathway and Impairs Cell Apoptosis During Vagina Luminal Formation in Puberty Mice.International journal of biological sciences · 2026Article
- Apoptosis promotes fertility inbioRxiv : the preprint server for biology · 2025Article
- Tegavivint triggers TECR-dependent nonapoptotic cancer cell death.Nature chemical biology · 2025Article
- Article
- Computational design of potent and selective binders of BAK and BAX.Science advances · 2025Article
- The BCL-2 protein family: from discovery to drug development.Cell death and differentiation · 2025Review
- Re-appraising assays on permeabilized blood cancer cells testing venetoclax or other BH3 mimetic agents selectively targeting pro-survival BCL2 proteins.Cell death and differentiation · 2025Article
570 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
21 authors at 5 institutions in 1 country.
Funding
Abstract
Proapoptotic Bcl-2 family members have been proposed to play a central role in regulating apoptosis. However, mice lacking bax display limited phenotypic abnormalities. As presented here, bak(-/-) mice were found to be developmentally normal and reproductively fit and failed to develop any age-related disorders. However, when Bak-deficient mice were mated to Bax-deficient mice to create mice lacking both genes, the majority of bax(-/-)bak(-/-) animals died perinatally with fewer than 10% surviving into adulthood. bax(-/-)bak(-/-) mice displayed multiple developmental defects, including persistence of interdigital webs, an imperforate vaginal canal, and accumulation of excess cells within both the central nervous and hematopoietic systems. Thus, Bax and Bak have overlapping roles in the regulation of apoptosis during mammalian development and tissue homeostasis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.