ArticleBritish journal of cancer2001
The clinical significance of MMP-1 expression in oesophageal carcinoma.
Article in British journal of cancer, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 49 citations in OpenAlex.
- Review
- Emerging technologies provide insights on cancer extracellular matrix biology and therapeutics.iScience · 2021Review
- Review
- Silencing microRNA-330-5p increases MMP1 expression and promotes an invasive phenotype in oesophageal adenocarcinoma.BMC cancer · 2019Article
- FGFRL1 deficiency reduces motility and tumorigenic potential of cells derived from oesophageal squamous cell carcinomas.Oncology letters · 2018Article
- Plasma matrix metalloproteinase 1 improves the detection and survival prediction of esophageal squamous cell carcinoma.Scientific reports · 2016Article
- Oncogenic KIT-containing exosomes increase gastrointestinal stromal tumor cell invasion.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Tumor-derived exosomes: A message delivery system for tumor progression.Communicative & integrative biology · 2014Review
- Inactivation of Rb in stromal fibroblasts promotes epithelial cell invasion.The EMBO journal · 2012Article
- The ERK MAP kinase-PEA3/ETV4-MMP-1 axis is operative in oesophageal adenocarcinoma.Molecular cancer · 2010Article
- MMP-1 is a (pre-)invasive factor in Barrett-associated esophageal adenocarcinomas and is associated with positive lymph node status.Journal of translational medicine · 2010Article
- Integration of targeted agents in the neo-adjuvant treatment of gastro-esophageal cancers.Therapeutic advances in medical oncology · 2009Article
- In vivo cancer biomarkers of esophageal neoplasia.Cancer biomarkers : section A of Disease markers · 2008Review
- Proteomic profiling of proteins dysregulted in Chinese esophageal squamous cell carcinoma.Journal of molecular medicine (Berlin, Germany) · 2007Article
- The collagenase-1 (MMP-1) gene promoter polymorphism - 1607/2G is associated with favourable prognosis in patients with colorectal cancer.British journal of cancer · 2007Article
- Clinical significance of matrix metalloproteinase-9 expression in esophageal squamous cell carcinoma.World journal of gastroenterology · 2005Article
- Clinical significance of elongation factor-1 delta mRNA expression in oesophageal carcinoma.British journal of cancer · 2004Article
- Increased expression of MMP-2 and MMP-9 in esophageal squamous cell carcinoma.Journal of cancer research and clinical oncology · 2004Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Matrix metalloproteinase-1 (MMP-1) is involved in the degradation of interstitial collagen and thus thought to play a role in invasion of carcinoma. We investigated 51 oesophageal carcinoma patients to clarify the significance of MMP-1. MMP-1 mRNA was demonstrated to be expressed exclusively in almost all carcinoma tissue specimens (T) (94.1%) by reverse transcription-polymerase chain reaction, but not found in normal mucosal tissue specimens (N). The mean T/N ratio of MMP-1 was 42.5 and cases with T/N > or = 10 had a higher incidence of cases involving muscularis propria than those with T/N < 10 which included all the cases involving the submucosa (P< 0.05). MMP-1 mRNA was significantly associated with both 40 kD (putative active MMP-1) and 50 kD (putative latent MMP-1) gelatinolytic bands (n = 17). These findings indicated that MMP-1 mRNA reflected the net function of MMP-1 and suggested MMP-1 to be involved in carcinoma invasive process. On the other hand, MMP-1 mRNA was inversely correlated with the patient prognosis (P< 0.01). These results indicated that MMP-1 might therefore play a crucial role in local invasion, but not in systemic dissemination. As a result, MMP-1 might be a novel prognostic factor independent from those previously reported in oesophageal carcinoma.
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