ArticleBritish journal of cancer2001
Chromosomal changes during development and progression of prostate adenocarcinomas.
Article in British journal of cancer, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 71 citations in OpenAlex.
- Article
- Molecular mechanisms involving prostate cancer racial disparity.American journal of clinical and experimental urology · 2017Review
- Molecular basis for prostate cancer racial disparities.Frontiers in bioscience (Landmark edition) · 2017Review
- Regulation of SRC kinases by microRNA-3607 located in a frequently deleted locus in prostate cancer.Molecular cancer therapeutics · 2014Article
- Allele frequency of ABO blood group antigen and the risk of esophageal cancer.BioMed research international · 2014Article
- The genomic landscape of prostate cancer.Frontiers in endocrinology · 2012Article
- CYP24A1 is an independent prognostic marker of survival in patients with lung adenocarcinoma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2011Article
- The candidate oncogene CYP24A1: A potential biomarker for colorectal tumorigenesis.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2010Article
- Molecular mechanisms involving prostate cancer racial disparity.American journal of translational research · 2009Article
- High-grade prostatic intraepithelial neoplasia of the prostate: the precursor lesion of prostate cancer.International journal of clinical and experimental pathology · 2009Article
- Mdm2-SNP309 polymorphism in prostate cancer: no evidence for association with increased risk or histopathological tumour characteristics.British journal of cancer · 2008Article
- FISH analysis of 107 prostate cancers shows that PTEN genomic deletion is associated with poor clinical outcome.British journal of cancer · 2007Article
- Array CGH identifies distinct DNA copy number profiles of oncogenes and tumor suppressor genes in chromosomal- and microsatellite-unstable sporadic colorectal carcinomas.Journal of molecular medicine (Berlin, Germany) · 2007Article
- Expression analysis of imbalanced genes in prostate carcinoma using tissue microarrays.British journal of cancer · 2007Article
- Genomic profiling of hormone-naïve lymph node metastases in patients with prostate cancer.Neoplasia (New York, N.Y.) · 2006Article
- Simultaneous tumour-like, atypical basal cell hyperplasia and acinar adenocarcinoma of the prostate: a comparative morphological and genetic approach.Virchows Archiv : an international journal of pathology · 2005Article
- Carcinoma of the prostate: inherited susceptibility, somatic gene defects and androgen receptors.Virchows Archiv : an international journal of pathology · 2004Review
- TMEFF2 is an androgen-regulated gene exhibiting antiproliferative effects in prostate cancer cells.Oncogene · 2002Article
- Relationship between ABO blood groups and carcinoma of esophagus and cardia in Chaoshan inhabitants of China.World journal of gastroenterology · 2001Article
- Identification of a gene frequently mutated in prostate tumors.Medical oncology (Northwood, London, England) · 2001Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chromosomal copy number changes were investigated in 16 prostate carcinomas, 12 prostatic intraepithelial neoplasias (PIN; 4 low-grade and 8 high-grade) adjacent to the invasive tumour areas, and 5 regional lymph node metastases. For this purpose, comparative genomic hybridization (CGH) was performed and a copy number karyotype for each histomorphological entity was created. CGH on microdissected cells from non-neoplastic glands was carried out on 3 different cases to demonstrate the reliability of the overall procedure. None of the non-neoplastic tissue samples revealed chromosome copy number changes. In PIN areas, chromosomal imbalances were detected on chromosomes 7, 8q, Xq (gains), and on 4q, 5q, 8p, 13q and 18q (losses). In the primary tumours, recurrent (at least 25% of cases) gains on chromosomes 12q and 15q, and losses on 2q, 4q, 5q, Xq, 13q and 18q became apparent. Losses on 8p and 6q as well as gains on 8q and of chromosome 7 were also detected at lower frequencies than previously reported. The pooled CGH data from the primary carcinomas revealed a novel region of chromosomal loss on 4q which is also frequently affected in other tumour entities like oesophageal adenocarcinomas and is supposed to harbour a new tumour suppressor gene. Gains on chromosome 9q and of chromosome 16 and loss on chromosome 13q were observed as common aberrations in metastases and primary tumours. These CGH results indicate an accumulation of chromosomal imbalances during the PIN-carcinoma-metastasis sequence and an early origin of tumour-specific aberrations in PIN areas.
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