ArticleNucleic acids research2001
Multiple sites of replication initiation in the human beta-globin gene locus.
Article in Nucleic acids research, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 47 citations in OpenAlex.
- Dynamic regulation of histone H3K9 is linked to the switch between replication and transcription at the Dbf4 origin-promoter locus.Cell cycle (Georgetown, Tex.) · 2016Article
- A replicator-specific binding protein essential for site-specific initiation of DNA replication in mammalian cells.Nature communications · 2016Article
- Peaks cloaked in the mist: the landscape of mammalian replication origins.The Journal of cell biology · 2015Review
- Chromatin structure and replication origins: determinants of chromosome replication and nuclear organization.Journal of molecular biology · 2014Review
- Activation of a human chromosomal replication origin by protein tethering.Nucleic acids research · 2013Article
- Oligodeoxynucleotide binding to (CTG) · (CAG) microsatellite repeats inhibits replication fork stalling, hairpin formation, and genome instability.Molecular and cellular biology · 2013Article
- Open chromatin structures regulate the efficiencies of pre-RC formation and replication initiation in Epstein-Barr virus.The Journal of cell biology · 2012Article
- Altered replication in human cells promotes DMPK (CTG)(n) · (CAG)(n) repeat instability.Molecular and cellular biology · 2012Article
- The dyad symmetry element of Epstein-Barr virus is a dominant but dispensable replication origin.PloS one · 2011Article
- A multiprotein complex necessary for both transcription and DNA replication at the β-globin locus.The EMBO journal · 2010Article
- Genomic study of replication initiation in human chromosomes reveals the influence of transcription regulation and chromatin structure on origin selection.Molecular biology of the cell · 2010Article
- Why are we where we are? Understanding replication origins and initiation sites in eukaryotes using ChIP-approaches.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2010Article
- Asymmetric bidirectional replication at the human DBF4 origin.Nature structural & molecular biology · 2008Article
- One-way PCR-based mapping of a replication initiation point (RIP).Nature protocols · 2008Article
- Unstable spinocerebellar ataxia type 10 (ATTCT*(AGAAT) repeats are associated with aberrant replication at the ATX10 locus and replication origin-dependent expansion at an ectopic site in human cells.Molecular and cellular biology · 2007Article
- High-throughput mapping of origins of replication in human cells.EMBO reports · 2007Article
- Identification of new human origins of DNA replication by an origin-trapping assay.Molecular and cellular biology · 2006Article
- Recruitment of ORC or CDC6 to DNA is sufficient to create an artificial origin of replication in mammalian cells.Genes & development · 2005Article
- The histone deacetylase inhibitor trichostatin A alters the pattern of DNA replication origin activity in human cells.Nucleic acids research · 2005Article
- Transcription factor binding and induced transcription alter chromosomal c-myc replicator activity.Molecular and cellular biology · 2004Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The cell cycle-dependent, ordered assembly of protein prereplicative complexes suggests that eukaryotic replication origins determine when genomic replication initiates. By comparison, the factors that determine where replication initiates relative to the sites of prereplicative complex formation are not known. In the human globin gene locus previous work showed that replication initiates at a single site 5' to the ss-globin gene when protein synthesis is inhibited by emetine. The present study has examined the pattern of initiation around the genetically defined ss-globin replicator in logarithmically growing HeLa cells, using two PCR-based nascent strand assays. In contrast to the pattern of initiation detected in emetine-treated cells, analysis of the short nascent strands at five positions spanning a 40 kb globin gene region shows that replication initiates at more than one site in non-drug-treated cells. Quantitation of nascent DNA chains confirmed that replication begins at several locations in this domain, including one near the initiation region (IR) identified in emetine-treated cells. However, the abundance of short nascent strands at another initiation site approximately 20 kb upstream is approximately 4-fold as great as that at the IR. The latter site abuts an early S phase replicating fragment previously defined at low resolution in logarithmically dividing cells.
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