ArticleJournal of virology2001
Self-association and mapping of the interaction domain of hepatitis E virus ORF3 protein.
Article in Journal of virology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 44 citations in OpenAlex.
- Stem Cell-Derived Culture Models of Hepatitis E Virus Infection.Cold Spring Harbor perspectives in medicine · 2019Review
- Palmitoylation mediates membrane association of hepatitis E virus ORF3 protein and is required for infectious particle secretion.PLoS pathogens · 2018Article
- Identification of critical residues in Hepatitis E virus macro domain involved in its interaction with viral methyltransferase and ORF3 proteins.Scientific reports · 2016Article
- Molecular Biology and Infection of Hepatitis E Virus.Frontiers in microbiology · 2016Review
- Characterization of self-assembled virus-like particles of dromedary camel hepatitis e virus generated by recombinant baculoviruses.Virus research · 2015Article
- Article
- The Hepatitis E virus intraviral interactome.Scientific reports · 2015Article
- Hepatitis e: molecular virology and pathogenesis.Journal of clinical and experimental hepatology · 2013Review
- RNA interference induces effective inhibition of mRNA accumulation and protein expression of SHEV ORF3 gene in vitro.Current microbiology · 2011Article
- The nonstructural protein 8 (nsp8) of the SARS coronavirus interacts with its ORF6 accessory protein.Virology · 2007Article
- Initiation at the third in-frame AUG codon of open reading frame 3 of the hepatitis E virus is essential for viral infectivity in vivo.Journal of virology · 2007Article
- The 41-amino-acid C-terminal region of the hepatitis E virus ORF3 protein interacts with bikunin, a kunitz-type serine protease inhibitor.Journal of virology · 2005Article
- In vitro and in vivo mutational analysis of the 3'-terminal regions of hepatitis e virus genomes and replicons.Journal of virology · 2005Article
- The hepatitis E virus open reading frame 3 protein activates ERK through binding and inhibition of the MAPK phosphatase.The Journal of biological chemistry · 2004Article
- The nucleocapsid protein of the SARS coronavirus is capable of self-association through a C-terminal 209 amino acid interaction domain.Biochemical and biophysical research communications · 2004Article
- The ORF2 protein of hepatitis E virus binds the 5' region of viral RNA.Journal of virology · 2004Article
- Detection of immunoglobulin M antibodies to hepatitis E virus by class capture enzyme immunoassay.Clinical and diagnostic laboratory immunology · 2003Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hepatitis E virus (HEV) is a major human pathogen in the developing world. In the absence of an in vitro culture system, very little information on the basic biology of the virus exists. A small protein (approximately 13.5 kDa) of unknown function, pORF3, is encoded by the third open reading frame of HEV. The N-terminal region of pORF3 is associated with the cytoskeleton using one of its hydrophobic domains. The C-terminal half of pORF3 is rich in proline residues and contains a putative src homology 3 (SH3) binding domain and a mitogen-activated protein kinase phosphorylation site. In this study, we demonstrate that pORF3 can homodimerize in vivo, using the yeast two-hybrid system. We have isolated a 43-amino-acid interaction domain of pORF3 which is capable of self-association in vivo and in vitro. The overlap of the dimerization domain with the SH3 binding and phosphorylation domains suggests that pORF3 may have a dimerization-dependent regulatory role to play in the signal transduction pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.