Evidence map›Paper›PMID 11160734›Full record

ArticleJournal of virology2001

Human GLI-2 is a tat activation response element-independent Tat cofactor.

C M Browning, M J Smith, N M Clark, B R Lane, C Parada, M Montano, V N KewalRamani, D R Littman, M Essex, R G Roeder and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 2 countries.

C M BrowningDepartment of Microbiology and Immunology, Ann Arbor, Michigan 48109-0640,USA.
M J Smith
N M Clark
B R Lane
C Parada
M Montano
V N KewalRamani
D R Littman
M Essex
R G Roeder
D M Markovitz
Office of Infectious Diseases · USHarvard University · USBipar · FRNew York University · USRockefeller University · USUniversity Medical Center · USUniversity of Michigan–Ann Arbor · US

Funding

MICHIGAN MEDICAL SCIENTIST TRAINING PROGRAMT32GM007863 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI COLLINS, KATHLEEN L. · 1985 to 2024
$38.3M
Cellular Biotechnology Training Program (CBTP)T32GM008353 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SCHWENDEMAN, ANNA · 1991 to 2021
$9.3M
Training Program in Tumor MicroenvironmentT32CA009676 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Maria G Castro, Analisa Virginia DiFeo · 1992 to 2026
$7.3M
Cellular Biotechnology Training Program (CBTP) - Years 31-35T32GM145304 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Guizhi Zhu · 2022 to 2026
$2.6M
REGULATION OF HIV2 TRANSCRIPTION BY THE PETS FACTORR01AI036685 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MARKOVITZ, DAVID MICHAEL · 1994 to 2002
$929k
PERI-KB MEDIATES HIV-2 ENHANCER ACTIVATION IN MONOCYTESK08AI001293 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CLARK, NINA M · 1994 to 1996
–
ACTIVATION OF THE HIV-2 ENHANCERR29AI030924 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MARKOVITZ, DAVID MICHAEL · 1991 to 1995
–
NCI NIH HHS T32 CA009676NIAID NIH HHS AI30924NIAID NIH HHS AI36685NIAID NIH HHS K08-AI01293NIGMS NIH HHS T32 GM007863NIGMS NIH HHS T32 GM008353NIGMS NIH HHS T32 GM145304
6 · The paper itself

Abstract

Zinc finger-containing GLI proteins are involved in the development of Caenorhabditis elegans, Xenopus, Drosophila, zebrafish, mice, and humans. In this study, we show that an isoform of human GLI-2 strongly synergizes with the Tat transactivating proteins of human immunodeficiency virus types 1 and 2 (HIV-1 and -2) and markedly stimulates viral replication. GLI-2 also synergizes with the previously described Tat cofactor cyclin T1 to stimulate Tat function. Surprisingly, GLI-2/Tat synergy is not dependent on either a typical GLI DNA binding site or an intact Tat activation response element but does require an intact TATA box. Thus, GLI-2/Tat synergy results from a mechanism of action which is novel both for a GLI protein and for a Tat cofactor. These findings link the GLI family of transcriptional and developmental regulatory proteins to Tat function and HIV replication.

Indexed as

Escherichia coli ProteinsReceptors, Cell SurfaceResponse ElementsTranscriptional ActivationAnimalsBacterial ProteinsCell LineChemoreceptor CellsCyclinsCyclin TDrosophila ProteinsGene Products, tatHIV-1HIV-2HIV InfectionsHumansBacterial ProteinsCCNT1 protein, humanCcnt1 protein, mouseCyclinsCyclin TCycT protein, DrosophilaDrosophila ProteinsEscherichia coli ProteinsGene Products, tatGLI2 protein, humanGli2 protein, mouseKruppel-Like Transcription FactorsMembrane ProteinsNuclear ProteinsReceptors, Cell SurfaceTar protein, E colitat Gene Products, Human Immunodeficiency VirusTranscription FactorsZinc Finger Protein Gli2

Identifiers

PMID11160734
PMCPMC114814
OpenAlexW2129328239

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.