ArticleJournal of virology2001
Rubella virus E2 signal peptide is required for perinuclear localization of capsid protein and virus assembly.
Article in Journal of virology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 31 citations in OpenAlex.
- Molecular and Structural Insights into the Life Cycle of Rubella Virus.Journal of virology · 2021Review
- Competitive Inhibition of the Endoplasmic Reticulum Signal Peptidase by Non-cleavable Mutant Preprotein Cargos.The Journal of biological chemistry · 2015Article
- Short self-interacting N-terminal region of rubella virus capsid protein is essential for cooperative actions of capsid and nonstructural p150 proteins.Journal of virology · 2014Article
- Phosphorylation and membrane association of the Rubella virus capsid protein is important for its anti-apoptotic function.Cellular microbiology · 2014Article
- Rubella virus capsid protein structure and its role in virus assembly and infection.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Determinants in the maturation of rubella virus p200 replicase polyprotein precursor.Journal of virology · 2012Article
- The Rubella virus capsid is an anti-apoptotic protein that attenuates the pore-forming ability of Bax.PLoS pathogens · 2011Article
- Identification of a dominant negative inhibitor of human zinc finger antiviral protein reveals a functional endogenous pool and critical homotypic interactions.Journal of virology · 2010Article
- The rubella virus capsid protein inhibits mitochondrial import.Journal of virology · 2010Article
- Analyses of phosphorylation events in the rubella virus capsid protein: role in early replication events.Journal of virology · 2006Article
- Analysis of rubella virus capsid protein-mediated enhancement of replicon replication and mutant rescue.Journal of virology · 2006Article
- Interactions between rubella virus capsid and host protein p32 are important for virus replication.Journal of virology · 2005Article
- Rubella virus capsid protein modulates viral genome replication and virus infectivity.Journal of virology · 2004Article
- Phosphorylation of rubella virus capsid regulates its RNA binding activity and virus replication.Journal of virology · 2003Article
- Intramembrane proteolysis promotes trafficking of hepatitis C virus core protein to lipid droplets.The EMBO journal · 2002Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The rubella virus (RV) structural proteins capsid, E2, and E1 are synthesized as a polyprotein precursor. The signal peptide that initiates translocation of E2 into the lumen of the endoplasmic reticulum remains attached to the carboxy terminus of the capsid protein after cleavage by signal peptidase. Among togaviruses, this feature is unique to RV. The E2 signal peptide has previously been shown to function as a membrane anchor for the capsid protein. In the present study, we demonstrate that this domain is required for RV glycoprotein-dependent localization of the capsid protein to the juxtanuclear region and subsequent virus assembly at the Golgi complex.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.