ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2001
Intensity-dependent, rapid activation of presynaptic metabotropic glutamate receptors at a central synapse.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The trial behind it
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Who cites it
30 citing papers in PubMed.
- A Presynaptic Group III mGluR Recruits Gβγ/SNARE Interactions to Inhibit Synaptic Transmission by Cone Photoreceptors in the Vertebrate Retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Mechanisms creating transient and sustained photoresponses in mammalian retinal ganglion cells.The Journal of general physiology · 2017Article
- The oscillation-like activity in bullfrog ON-OFF retinal ganglion cell.Cognitive neurodynamics · 2016Article
- Properties of a Glutamatergic Synapse Controlling Information Output from Retinal Bipolar Cells.PloS one · 2015Article
- ON-OFF Interactions in the Retina: Role of Glycine and GABA.Current neuropharmacology · 2014Article
- Presynaptic inhibition by α2 receptor/adenylate cyclase/PDE4 complex at retinal rod bipolar synapse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Disinhibitory recruitment of NMDA receptor pathways in retina.Journal of neurophysiology · 2014Article
- Kainate receptors mediate signaling in both transient and sustained OFF bipolar cell pathways in mouse retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Differential modulation of retinal ganglion cell light responses by orthosteric and allosteric metabotropic glutamate receptor 8 compounds.Neuropharmacology · 2013Article
- Extrasynaptic glutamate and inhibitory neurotransmission modulate ganglion cell participation during glutamatergic retinal waves.Journal of neurophysiology · 2013Article
- Cross inhibition from ON to OFF pathway improves the efficiency of contrast encoding in the mammalian retina.Journal of neurophysiology · 2012Article
- "mGlu Receptors in the Retina" - WIREs Membrane Transport and Signaling.Wiley interdisciplinary reviews. Membrane transport and signaling · 2012Article
- Light-evoked lateral GABAergic inhibition at single bipolar cell synaptic terminals is driven by distinct retinal microcircuits.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- An intrinsic neural oscillator in the degenerating mouse retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- GABA(B) receptor feedback regulation of bipolar cell transmitter release.The Journal of physiology · 2010Article
- Selective activation of mGluR8 receptors modulates retinal ganglion cell light responses.Neuroscience · 2010Article
- A computational study on the role of gap junctions and rod Ih conductance in the enhancement of the dynamic range of the retina.PloS one · 2009Article
- Parallel ON and OFF cone bipolar inputs establish spatially coextensive receptive field structure of blue-yellow ganglion cells in primate retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Synaptic inhibition by glycine acting at a metabotropic receptor in tiger salamander retina.The Journal of physiology · 2008Article
- Spatial properties and functional organization of small bistratified ganglion cells in primate retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Synaptic signals from retinal bipolar cells were monitored by measuring EPSCs in ganglion cells voltage-clamped at -70 mV. Spontaneous EPSCs were strongly suppressed by l-2-amino-4-phosphonobutyrate (AP-4), an agonist at group III metabotropic glutamate receptors (mGluRs). Agonists of group I or II mGluRs were ineffective. AP-4 also suppressed ganglion cell EPSCs evoked by bipolar cell stimulation using potassium puffs, sucrose puffs, or zaps of current (0.5-1 microA). In addition, AP-4 suppressed Off EPSCs evoked by dim-light stimuli. This indicates that group III mGluRs mediate a direct suppression of bipolar cell transmitter release. An mGluR antagonist, (RS)-alpha-cyclopropyl-4-phosphonophenylyglycine (CPPG), blocked the action of AP-4. When bipolar cells were weakly stimulated, AP-4 produced a large suppression of the EPSC, but CPPG alone had little effect. Conversely, when bipolar cells were strongly stimulated, CPPG produced an enhancement of the EPSC, but AP-4 alone had little effect. This indicates that endogenous feedback regulates bipolar cell transmitter release and that the dynamic range of the presynaptic metabotropic autoreceptor is similar to that of the postsynaptic ionotropic receptor. Furthermore, the feedback is rapid and intensity-dependent. Hence, concomitant activation of presynaptic and postsynaptic glutamate receptors shapes the responses of ganglion cells.
Indexed as
Identifiers
11160453PMC6763806What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.