ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2001
Distinct Localization of P2X receptors at excitatory postsynaptic specializations.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 107 papers.
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Who cites it
107 citing papers in PubMed, 259 citations in OpenAlex.
- Regulation of GABAergic neurotransmission by purinergic receptors in brain physiology and disease.Purinergic signalling · 2025Review
- The spiny relationship between parallel fibers, climbing fibers, and Purkinje cells.Frontiers in physiology · 2025Review
- Feedback facilitation by adenosine APurinergic signalling · 2024Article
- Joubert syndrome-derived induced pluripotent stem cells show altered neuronal differentiation in vitro.Cell and tissue research · 2024Article
- Role of spinal astrocytes through the perisynaptic astrocytic process in pathological pain.Molecular brain · 2023Review
- Analysis of Spatial and Temporal Distribution of Purinergic P2 Receptors in the Mouse Hippocampus.International journal of molecular sciences · 2021Article
- Contribution of P2X4 receptor in pain associated with rheumatoid arthritis: a review.Purinergic signalling · 2021Review
- Impaired calcium signaling in astrocytes modulates autism spectrum disorder-like behaviors in mice.Nature communications · 2021Article
- Increased surface P2X4 receptor regulates anxiety and memory in P2X4 internalization-defective knock-in mice.Molecular psychiatry · 2021Article
- MeCP2 gates spatial learning-induced alternative splicing events in the mouse hippocampus.Molecular brain · 2020Article
- Implication of Neuronal Versus Microglial P2X4 Receptors in Central Nervous System Disorders.Neuroscience bulletin · 2020Review
- Contribution of P2X4 Receptors to CNS Function and Pathophysiology.International journal of molecular sciences · 2020Review
- To Inhibit or Enhance? Is There a Benefit to Positive Allosteric Modulation of P2X Receptors?Frontiers in pharmacology · 2020Review
- In the line-up: deleted genes associated with DiGeorge/22q11.2 deletion syndrome: are they all suspects?Journal of neurodevelopmental disorders · 2019Review
- Purinergic implication in amyotrophic lateral sclerosis-from pathological mechanisms to therapeutic perspectives.Purinergic signalling · 2019Review
- Assessment of glutamatergic synaptic transmission and plasticity in brain slices: relevance to bioelectronic approaches.Bioelectronic medicine · 2019Article
- Reduced P2X receptor levels are associated with antidepressant effect in the learned helplessness model.PeerJ · 2019Article
- Preclinical evaluation of avermectins as novel therapeutic agents for alcohol use disorders.Psychopharmacology · 2018Review
- Tonotopic action potential tuning of maturing auditory neurons through endogenous ATP.The Journal of physiology · 2017Article
- KThe Journal of physiology · 2017Article
47 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
ATP mediates fast excitatory synaptic transmission in some regions of the central nervous system through activation of P2X receptors. Nonetheless, the functional significance of ATP-mediated neurotransmission is not yet understood. Using postembedding immunocytochemistry, we describe the distribution of P2X(2), P2X(4), and P2X(6) subunits in cerebellum and in the CA1 region of the hippocampus. Dendritic spines of cerebellar Purkinje cells showed immunogold labeling for all three subunits when apposed to parallel fiber (PF) terminals. In contrast, no immunogold labeling was observed on dendritic spines or cell bodies receiving inputs from climbing fibers and basket cells, respectively. In CA1 pyramidal cells, postsynaptic membranes apposed to terminals of Schaffer collaterals were immunogold-labeled for P2X(2), P2X(4), and P2X(6) subunits. Immunolabeling was also observed perisynaptically and intracellularly in relation to membranes of the endoplasmic reticulum. The analysis of the tangential distribution of gold particles showed that they were preferentially located at the peripheral portion of the postsynaptic specialization of both parallel fiber and Schaffer collateral synapses. By double imunogold labeling using antibodies for P2X receptor subunits and GluR2/3 subunits of the AMPA glutamate receptors, we show that synapses expressing P2X receptors are also glutamatergic. The present study shows for the first time qualitatively and quantitatively the precise localization of P2X receptors in brain. Moreover, our data indicate that P2X receptors may play a significant role at glutamatergic synapses.
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Identifiers
11160443PMC6763822W1699660695What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.