ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2001
Quantitative relationship between transmitter release and calcium current at the calyx of held synapse.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 111 papers.
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Who cites it
111 citing papers in PubMed.
- Reorganization of synchronous and asynchronous release in developing hippocampal autaptic neurons of mice.Physiological reports · 2026Article
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- Recovery of Dexterous Motor Control via Non-Monosynaptic Corticospinal Pathways.medRxiv : the preprint server for health sciences · 2026Article
- Munc13-1 couples DAG and CaScience advances · 2026Article
- Depression of synaptic outputs by reduction of CaFrontiers in molecular neuroscience · 2026Article
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- Number and relative abundance of synaptic vesicles in functionally distinct priming states determine synaptic strength and short-term plasticity.The Journal of physiology · 2025Article
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- A sequential two-step priming scheme reproduces diversity in synaptic strength and short-term plasticity.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Transient docking of synaptic vesicles: Implications and mechanisms.Current opinion in neurobiology · 2022Review
- Three small vesicular pools in sequence govern synaptic response dynamics during action potential trains.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Presynaptic Mitochondria Communicate With Release Sites for Spatio-Temporal Regulation of Exocytosis at the Motor Nerve Terminal.Frontiers in synaptic neuroscience · 2022Article
- Munc13-1 is a CaNeuron · 2021Article
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- RIM-Binding Protein 2 Organizes CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Large, Stable Spikes Exhibit Differential Broadening in Excitatory and Inhibitory Neocortical Boutons.Cell reports · 2021Article
- Primary and secondary motoneurons use different calcium channel types to control escape and swimming behaviors in zebrafish.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Direct Observation of Vesicle Transport on the Synaptic Ribbon Provides Evidence That Vesicles Are Mobilized and Prepared Rapidly for Release.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Differentially poised vesicles underlie fast and slow components of release at single synapses.The Journal of general physiology · 2020Article
- Article
51 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A newly developed deconvolution method (Neher and Sakaba, 2001) allowed us to resolve the time course of neurotransmitter release at the calyx of Held synapse and to quantify some basic aspects of transmitter release. First, we identified a readily releasable pool (RRP) of synaptic vesicles. We found that the size of the RRP, when tested with trains of strong stimuli, was constant regardless of the exact stimulus patterns, if stimuli were confined to a time interval of approximately 60 msec. For longer-lasting stimulus patterns, recruitment of new vesicles to the RRP made a substantial contribution to the total release. Second, the cooperativity of transmitter release as a function of Ca(2+) current was estimated to be 3-4, which confirmed previous results (Borst and Sakmann, 1999; Wu et al., 1999). Third, an initial small Ca(2+) influx increased the efficiency of Ca(2+) currents in subsequent transmitter release. This type of facilitation was blocked by a high concentration of EGTA (0.5 mm). Fourth, the release rates of synaptic vesicles at this synapse turned out to be heterogeneous: once a highly Ca(2+)-sensitive population of vesicles was consumed, the remaining vesicles released at lower rates. These components of release were more clearly separated in the presence of 0.5 mm EGTA, which prevented the buildup of residual Ca(2+). Conversely, raising the extracellular Ca(2+) concentration facilitated the slower population such that its release characteristics became more similar to those of the faster population under standard conditions. Heterogeneous release probabilities are expected to support the maintenance of synaptic transmission during high-frequency stimulation.
Indexed as
Identifiers
11160426PMC6763832What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.