ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2001
Nerve growth factor antiserum induces axotomy-like changes in neuropeptide expression in intact sympathetic and sensory neurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 159 citations in OpenAlex.
- The Effects of Fasinumab on Peripheral Nerve Function and Ganglion Anatomy: Results From a Randomized, Double-Blind, Placebo-Controlled Study in Patients With Pain Due to Osteoarthritis of the Knee or Hip, and a Series of Nonclinical Studies.Current therapeutic research, clinical and experimental · 2025Article
- Tissue damage-induced axon injury-associated responses in sensory neurons: requirements, prevention, and potential role in persistent post-surgical pain.Frontiers in pain research (Lausanne, Switzerland) · 2025Article
- Article
- PACAP/PAC1 Regulation of Inflammation via Catecholaminergic Neurons in a Model of Multiple Sclerosis.Journal of molecular neuroscience : MN · 2019Article
- Macrophage biology in the peripheral nervous system after injury.Progress in neurobiology · 2019Review
- Retrograde influences of SCG axotomy on uninjured preganglionic neurons.Brain research · 2018Article
- Regulation of axonal regeneration following spinal cord injury in the lamprey.Journal of neurophysiology · 2017Article
- Renal denervation in male rats with heart failure improves ventricular sympathetic nerve innervation and function.American journal of physiology. Regulatory, integrative and comparative physiology · 2017Article
- Activation of neurotrophins in lumbar dorsal root probably contributes to neuropathic pain after spinal nerve ligation.Iranian journal of basic medical sciences · 2017Article
- SP, CGRP changes in pyridoxine induced neuropathic dogs with nerve growth factor gene therapy.BMC neuroscience · 2016Article
- Neurotrophins and Neuropathic Pain: Role in Pathobiology.Molecules (Basel, Switzerland) · 2015Review
- Cell intrinsic control of axon regeneration.EMBO reports · 2014Review
- CaMKK-CaMK1a, a new post-traumatic signalling pathway induced in mouse somatosensory neurons.PloS one · 2014Article
- Article
- Axotomy-induced changes in the chemical coding pattern of colon projecting calbindin-positive neurons in the inferior mesenteric ganglia of the pig.Journal of molecular neuroscience : MN · 2013Article
- STAT3 integrates cytokine and neurotrophin signals to promote sympathetic axon regeneration.Molecular and cellular neurosciences · 2013Article
- Expression changes and bioinformatic analysis of Wallerian degeneration after sciatic nerve injury in rat.Neuroscience bulletin · 2013Article
- Laser therapy and pain-related behavior after injury of the inferior alveolar nerve: possible involvement of neurotrophins.Journal of neurotrauma · 2013Article
- Activation of extracellular signal-regulated protein kinase 5 is essential for cystitis- and nerve growth factor-induced calcitonin gene-related peptide expression in sensory neurons.Molecular pain · 2012Article
- Gene expression profiling of the rat sciatic nerve in early Wallerian degeneration after injury.Neural regeneration research · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Axonal transection of adult sympathetic and sensory neurons leads to a decrease in their content of target-derived nerve growth factor (NGF) and to dramatic changes in the expression of several neuropeptides and enzymes involved in transmitter biosynthesis. For example, axotomy of sympathetic neurons in the superior cervical ganglion (SCG) dramatically increases levels of galanin, vasoactive intestinal peptide (VIP), and substance P and their respective mRNAs and decreases mRNA levels for neuropeptide Y (NPY) and tyrosine hydroxylase (TH). Axotomy of sensory neurons in lumbar dorsal root ganglia (DRG) increases protein and mRNA levels for galanin and VIP and decreases levels for substance P and calcitonin gene-related peptide (CGRP). To assess whether reduction in the availability of endogenous NGF might play an important role in triggering these changes, we injected nonoperated animals with an antiserum against NGF (alphaNGF). alphaNGF increased levels of peptide and mRNA for galanin and VIP in neurons in both the SCG and DRG. NPY protein and mRNA were decreased in the SCG, but levels of TH protein and mRNA remained unchanged. In sensory neurons the levels of SP and CGRP protein decreased after alphaNGF treatment. These data suggest that the reduction in levels of NGF in sympathetic and sensory neurons after axotomy is partly responsible for the subsequent changes in neuropeptide expression. Thus, the peptide phenotype of these axotomized neurons is regulated both by the induction of an "injury factor," leukemia inhibitory factor, as shown previously, and by the reduction in a target-derived growth factor.
Indexed as
Identifiers
11160417PMC6763811W2135600240What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.