ArticleThe Journal of clinical investigation2001
Glucocorticoids upregulate CD40 ligand expression and induce CD40L-dependent immunoglobulin isotype switching.
Article in The Journal of clinical investigation, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.
- Dexamethasone and overall survival and progression free survival in patients with newly diagnosed glioblastoma: a meta-analysis.Journal of neuro-oncology · 2024Pooled it
- Predictors of poor response during asthma therapy differ with definition of outcome.Pharmacogenomics · 2009Trial
- Efficacy and immune-inflammatory modulation of combined glucocorticoid and anti-tuberculosis therapy in patients with bronchial asthma and pulmonary tuberculosis.American journal of translational research · 2026Article
- Induction of natural IgE by glucocorticoids.The Journal of experimental medicine · 2022Article
- Keratinocytes control skin immune homeostasis through de novo-synthesized glucocorticoids.Science advances · 2021Article
- Impact of immunosuppressive and antifungal drugs on PBMC- and whole blood-based flow cytometric CD154Medical microbiology and immunology · 2020Article
- TRIM21 Dysfunction Enhances Aberrant B-Cell Differentiation in Autoimmune Pathogenesis.Frontiers in immunology · 2020Article
- Glucocorticoids, Sex Hormones, and Immunity.Frontiers in immunology · 2018Review
- Immune regulation by glucocorticoids.Nature reviews. Immunology · 2017Review
- Corticosteroids inhibit anti-IgE activities of specialized proresolving mediators on B cells from asthma patients.JCI insight · 2017Article
- Article
- A missense mutation in TFRC, encoding transferrin receptor 1, causes combined immunodeficiency.Nature genetics · 2016Article
- Abundant immunoglobulin E-positive cells in skin lesions support an allergic etiology of atopic dermatitis in the elderly.Journal of the European Academy of Dermatology and Venereology : JEADV · 2013Article
- DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation.Nature immunology · 2012Article
- Effects of systemic versus local administration of corticosteroids on mucosal tolerance.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Dexamethasone effects in the Strongyloides venezuelensis infection in a murine model.The American journal of tropical medicine and hygiene · 2011Article
- Mechanisms of IgE Inflammation.Current allergy and asthma reports · 2011Review
- Ligation of CD46 to CD40 inhibits CD40 signaling in B cells.International immunology · 2011Article
- The role of immunoglobulin E and immune inflammation: implications in allergic rhinitis.Current allergy and asthma reports · 2005Review
- IL-13 R130Q, a common variant associated with allergy and asthma, enhances effector mechanisms essential for human allergic inflammation.The Journal of clinical investigation · 2005Article
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3 authors at 2 institutions in 1 country.
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Abstract
IL-4 and CD40 ligation are essential for IgE synthesis by B cells. We have shown previously that hydrocortisone (HC) induces IgE synthesis in IL-4-stimulated human B cells. In this study we demonstrate that HC fails to induce IgE synthesis in B cells from CD40 ligand-deficient (CD40L-deficient) patients. Disruption of CD40L-CD40 interactions by soluble CD40-Ig fusion protein or anti-CD40L mAb blocked the capacity of HC to induce IgE synthesis in normal B cells. HC upregulated CD40L mRNA expression in PBMCs and surface expression of CD40L in PBMCs as well as in purified populations of T and B cells. Upregulation of CD40L mRNA in PBMCs occurred 3 hours after stimulation with HC and was inhibited by actinomycin D. Upregulation of CD40L mRNA and induction of IgE synthesis by HC were inhibited by the steroid hormone receptor antagonist RU-486. These results indicate that ligand-mediated activation of the glucocorticoid receptor upregulates CD40L expression in human lymphocytes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.