ArticleThe Journal of clinical investigation2001
Leukemia inhibitory factor inhibits HIV-1 replication and is upregulated in placentae from nontransmitting women.
Article in The Journal of clinical investigation, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 86 citations in OpenAlex.
- Multiple Inhibitory Factors Act in the Late Phase of HIV-1 Replication: a Systematic Review of the Literature.Microbiology and molecular biology reviews : MMBR · 2018Pooled it
- Placenta - A Competent, But Not Infallible, Antiviral and Antiparasitic Barrier.Reproductive sciences (Thousand Oaks, Calif.) · 2025Review
- The Complex Role of CD8+ T Cells in Placental HIV Infection.European journal of immunology · 2025Review
- Effects of Antiretroviral Treatment on Central and Peripheral Immune Response in Mice with EcoHIV Infection.Cells · 2024Article
- Leukemia inhibitory factor, a double-edged sword with therapeutic implications in human diseases.Molecular therapy : the journal of the American Society of Gene Therapy · 2023Review
- Susceptibilities of CNS Cells towards Rabies Virus Infection Is Linked to Cellular Innate Immune Responses.Viruses · 2022Article
- ZIKV can infect human term placentas in the absence of maternal factors.Communications biology · 2022Article
- The emerging role of leukemia inhibitory factor in cancer and therapy.Pharmacology & therapeutics · 2021Review
- Placental Immune Responses to Viruses: Molecular and Histo-Pathologic Perspectives.International journal of molecular sciences · 2021Review
- Recent insights into targeting the IL-6 cytokine family in inflammatory diseases and cancer.Nature reviews. Immunology · 2018Review
- Human Cytomegalovirus Enhances Placental Susceptibility and Replication of Human Immunodeficiency Virus Type 1 (HIV-1), Which May Facilitate In Utero HIV-1 Transmission.The Journal of infectious diseases · 2018Article
- Adding new dimensions: towards an integrative understanding of HIV-1 spread.Nature reviews. Microbiology · 2014Review
- Immunology of pediatric HIV infection.Immunological reviews · 2013Review
- Role of the placenta in adverse perinatal outcomes among HIV-1 seropositive women.Journal of Nippon Medical School = Nippon Ika Daigaku zasshi · 2013Review
- Study of HIV-1 transmission across cervical mucosa to tonsil tissue cells using an organ culture.American journal of reproductive immunology (New York, N.Y. : 1989) · 2013Article
- Placental Hofbauer cells limit HIV-1 replication and potentially offset mother to child transmission (MTCT) by induction of immunoregulatory cytokines.Retrovirology · 2012Article
- Analysis of multiple cell reservoirs expressing unspliced HIV-1 gag-pol mRNA in patients on antiretroviral therapy.Future virology · 2012Article
- Interplay between HIV-1 infection and host microRNAs.Nucleic acids research · 2012Article
- HIV-1 Nef breaches placental barrier in rat model.PloS one · 2012Article
- Inference of surface membrane factors of HIV-1 infection through functional interaction networks.PloS one · 2010Article
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Authors and funding
10 authors at 6 institutions in 2 countries.
Funding
Abstract
The placenta may play a critical role in inhibiting vertical transmission of HIV-1. Here we demonstrate that leukemia inhibitory factor (LIF) is a potent endogenous HIV-1-suppressive factor produced locally in placentae. In vitro, LIF exerted a potent, gp130-LIFRbeta-dependent, HIV coreceptor-independent inhibition of HIV-1 replication with IC50 values between 0.1 pg/ml and 0.7 pg/ml, depending on the HIV-1 isolate. LIF also inhibited HIV-1 in placenta and thymus tissues grown in ex vivo organ culture. The level of LIF mRNA and the incidence of LIF protein-expressing cells were significantly greater in placentae from HIV-1-infected women who did not transmit HIV-1 to their fetuses compared with women who transmitted the infection, but they were not significantly different from placentae of uninfected mothers. These findings demonstrate a novel pathway for endogenous HIV suppression that may prove to be an effective immune therapy for HIV infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.