ArticleThe Journal of clinical investigation2001
Chemokine-receptor activation by env determines the mechanism of death in HIV-infected and uninfected T lymphocytes.
Article in The Journal of clinical investigation, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 94 citations in OpenAlex.
- Immune Alterations and Viral Reservoir Atlas in SIV-Infected Chinese Rhesus Macaques.Infectious disease reports · 2025Review
- Temsavir blocks the immunomodulatory activities of HIV-1 soluble gp120.Cell chemical biology · 2023Article
- HIV-1 release requires Nef-induced caspase activation.PloS one · 2023Article
- Frequency and functional profile of circulating TCRαβBMC infectious diseases · 2022Article
- The Interplay of HIV and Autophagy in Early Infection.Frontiers in microbiology · 2021Review
- The anti-caspase inhibitor Q-VD-OPH prevents AIDS disease progression in SIV-infected rhesus macaques.The Journal of clinical investigation · 2018Article
- CCR5 interaction with HIV-1 Env contributes to Env-induced depletion of CD4 T cells in vitro and in vivo.Retrovirology · 2016Article
- Diversity and Inter-Connections in the CXCR4 Chemokine Receptor/Ligand Family: Molecular Perspectives.Frontiers in immunology · 2015Review
- HIV-1 subtype C unproductively infects human cardiomyocytes in vitro and induces apoptosis mitigated by an anti-Gp120 aptamer.PloS one · 2014Article
- Critical roles for Akt kinase in controlling HIV envelope-mediated depletion of CD4 T cells.Retrovirology · 2013Article
- Antibody against integrin lymphocyte function-associated antigen 1 inhibits HIV type 1 infection in primary cells through caspase-8-mediated apoptosis.AIDS research and human retroviruses · 2013Article
- T-Cell Signaling in HIV-1 Infection.The open virology journal · 2013Article
- Secretion modification region-derived peptide disrupts HIV-1 Nef's interaction with mortalin and blocks virus and Nef exosome release.Journal of virology · 2012Article
- Article
- Potentiation of EBV-induced B Cell transformation by CXCR4-tropic, but not CCR5-tropic, HIV gp120: implications for HIV-associated lymphomagenesis.AIDS research and human retroviruses · 2011Article
- CD4+ T cell depletion in human immunodeficiency virus (HIV) infection: role of apoptosis.Viruses · 2011Review
- Limited CD4+ T cell proliferation leads to preservation of CD4+ T cell counts in SIV-infected sooty mangabeys.Proceedings. Biological sciences · 2010Article
- Abortive HIV infection mediates CD4 T cell depletion and inflammation in human lymphoid tissue.Cell · 2010Article
- Mechanisms of HIV envelope-induced T lymphocyte apoptosis.Virologica Sinica · 2010Review
- Genetic characterization of HIV type 1 Nef-induced vesicle secretion.AIDS research and human retroviruses · 2010Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
There is considerable confusion concerning the mechanism of lymphocyte death during HIV infection. During the course of HIV infection, M-tropic viruses (R5) that use CCR5 chemokine coreceptors frequently evolve to T-tropic viruses (X4) that use CXCR4 receptors. In this study we show that activation of the CD4 or CCR5 receptor by R5 HIVenv causes a caspase 8-dependent death of both uninfected and infected CD4 T cells. In contrast, CXCR4 activation by X4 HIVenv induces a caspase-independent death of both uninfected CD4 and CD8 T cells and infected CD4 cells. These results suggest that activation of the chemokine receptor by HIVenv determines the mechanism of death for both infected and uninfected T lymphocytes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.