Evidence map›Paper›PMID 11160021›Full record

ArticleInfection and immunity2001

Expression, extracellular secretion, and immunogenicity of the Plasmodium falciparum sporozoite surface protein 2 in Salmonella vaccine strains.

O G Gómez-Duarte, M F Pasetti, A Santiago, M B Sztein, S L Hoffman, M M Levine

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infection and immunity, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
6.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 2 countries.

O G Gómez-DuarteCenter for Vaccine Development, Department of Medicine, School of Medicine, University of Maryland, Baltimore, Maryland 21201, USA.
M F Pasetti
A Santiago
M B Sztein
S L Hoffman
M M Levine
University of Maryland, Baltimore · US

Funding

RECOMBINANT &LIVE ORAL SALMONELLA TYPHI HYBRID VACCINESR01AI029471 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI LEVINE, MYRON MAX · 1990 to 2008
$3.7M
MULTIVALENT SALMONELLA TYPHI BASED MALARIA VACCINESR01AI040297 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI LEVINE, MYRON MAX · 1997 to 2004
$1.8M
CONTROL MESURES IN AGING AND INFECTIOUS DISEASEN01AI045251 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI LEVINE, MYRON MAX · 1994 to 2000
–
NIAID NIH HHS N01-AI-45251NIAID NIH HHS R01 AI029471NIAID NIH HHS R01 AI040297NIAID NIH HHS R01AI29741NIAID NIH HHS R01AI40297
6 · The paper itself

Abstract

Deleting transmembrane alpha-helix motifs from Plasmodium falciparum sporozoite surface protein (SSP-2) allowed its secretion from Salmonella enterica serovar Typhimurium SL3261 and S. enterica serovar Typhi CVD 908-htrA by the Hly type I secretion system. In mice immunized intranasally, serovar Typhimurium constructs secreting SSP-2 stimulated greater gamma interferon splenocyte responses than did nonsecreting constructs (P = 0.04).

Indexed as

AnimalsAntigens, ProtozoanFemaleImmunizationLymphocyte ActivationMalaria VaccinesMiceMice, Inbred C57BLMolecular WeightPlasmodium falciparumProtozoan ProteinsSalmonellaT-Lymphocytes, CytotoxicVaccines, DNAAntigens, ProtozoanMalaria VaccinesProtozoan Proteinssporozoite-surface protein 2, Plasmodium yoelliVaccines, DNA

Identifiers

PMID11160021
PMCPMC98005
OpenAlexW2157129800

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.