ArticleInfection and immunity2001
Expression of tumor necrosis factor alpha and interleukin 1 beta in jejuna of volunteers after experimental challenge with Cryptosporidium parvum correlates with exposure but not with symptoms.
Article in Infection and immunity, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 49 citations in OpenAlex.
- Microphysiological gut-on-chip enables extendedFrontiers in cellular and infection microbiology · 2025Article
- Regulatory Functions of Hypoxia in Host-Parasite Interactions: A Focus on Enteric, Tissue, and Blood Protozoa.Microorganisms · 2023Review
- The Efficacy of Citrus maxima Peels Aqueous Extract Against Cryptosporidiosis in Immunecompromised Mice.Acta parasitologica · 2021Article
- A rapid IL-17 response to Cryptosporidium parvum in the bovine intestine.Veterinary immunology and immunopathology · 2017Article
- Cryptosporidiosis-an overview.Journal of biomedical research · 2012Article
- Identification and immunological characterization of three potential vaccinogens against Cryptosporidium species.Clinical and vaccine immunology : CVI · 2011Article
- The cell biology of cryptosporidium infection.Microbes and infection · 2011Review
- Human immune responses in cryptosporidiosis.Future microbiology · 2010Review
- Intestinal immune response to human Cryptosporidium sp. infection.Infection and immunity · 2008Review
- Role of tumor necrosis factor alpha in development of immunity against Cryptosporidium parvum infection.Infection and immunity · 2006Article
- Differential regulation of beta-defensin gene expression during Cryptosporidium parvum infection.Infection and immunity · 2004Article
- Pathogenicity of Cryptosporidium parvum--evaluation of an animal infection model.Veterinary parasitology · 2003Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Jejunal biopsies from volunteers challenged with Cryptosporidium parvum were examined for tumor necrosis factor alpha (TNF-alpha) and interleukin (IL)-1 beta mRNA. Postchallenge biopsies from 15 of 28 (54%) volunteers expressed TNF-alpha; 14% expressed IL-1 beta. Cytokine expression did not correlate with enteric symptoms, suggesting that TNF-alpha and IL-1 beta are not key mediators of diarrhea in human cryptosporidiosis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.