ArticleInfection and immunity2001
Schistosome infection stimulates host CD4(+) T helper cell and B-cell responses against a novel egg antigen, thioredoxin peroxidase.
Article in Infection and immunity, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 55 citations in OpenAlex.
- Human serum activates the tegument of female schistosomes and supports recovery from Praziquantel.Parasitology research · 2021Article
- Article
- Cytokine patterns in experimental schistosomiasis mansoni infected mice treated with silymarin.Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2016Article
- Specific humoral response of hosts with variable schistosomiasis susceptibility.Immunology and cell biology · 2016Article
- Induction and regulation of pathogenic Th17 cell responses in schistosomiasis.Seminars in immunopathology · 2012Review
- Peroxiredoxins in parasites.Antioxidants & redox signaling · 2012Review
- Moonlighting by different stressors: crystal structure of the chaperone species of a 2-Cys peroxiredoxin.Structure (London, England : 1993) · 2012Article
- The redox biology of schistosome parasites and applications for drug development.Current pharmaceutical design · 2012Review
- Fasciola hepatica and Schistosoma mansoni: identification of common proteins by comparative proteomic analysis.The Journal of parasitology · 2011Article
- Article
- Characterization of the methionine sulfoxide reductases of Schistosoma mansoni.The Journal of parasitology · 2009Article
- The embryonic development of Schistosoma mansoni eggs: proposal for a new staging system.Development genes and evolution · 2009Article
- Helminth 2-Cys peroxiredoxin drives Th2 responses through a mechanism involving alternatively activated macrophages.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2008Article
- Profiling Schistosoma mansoni development using serial analysis of gene expression (SAGE).Experimental parasitology · 2007Article
- New perspectives on host-parasite interplay by comparative transcriptomic and proteomic analyses of Schistosoma japonicum.PLoS pathogens · 2006Article
- Evaluation of CD4(+)/CD8(+) status and urinary tract infections associated with urinary schistosomiasis among some rural Nigerians.African health sciences · 2005Article
- Thioredoxin peroxidase secreted by Fasciola hepatica induces the alternative activation of macrophages.Infection and immunity · 2005Article
- Novel phage display-based subtractive screening to identify vaccine candidates of Brugia malayi.Infection and immunity · 2004Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Egg granuloma formation during schistosome infections is mediated by CD4(+) T helper (Th) cells sensitized to egg antigens; however, most of the relevant sensitizing egg antigens are still unknown. Here we show that schistosome thioredoxin peroxidase (TPx)-1 is a novel T- and B-cell egg antigen in schistosome-infected mice. CD4(+) Th cell responses to fractionated egg components identified a significant response against a 26-kDa antigen; a partial amino acid sequence of this antigen was found to be identical to that of Schistosoma mansoni TPx-1. The native TPx-1 elicited significant proliferative responses as well as gamma interferon (IFN-gamma), interleukin-2 (IL-2), IL-4, and IL-5 secretion in CD4(+) cells from 8.5-week-infected CBA and C57BL/6 mice. By comparison, recombinant TPx-1 elicited a smaller, more type 1-polarized response, with significant production of IFN-gamma and IL-2, less IL-5, and essentially no IL-4. In C57BL/6 mice the responses to TPx-1 were relatively more prominent than that directed against the major egg antigen, Sm-p40, whereas in CBA mice the reverse was true. B-cell responses were also monitored in infected C57BL/6, C3H, CBA, and BALB/c mice. All strains had significant antibody levels against the TPx-1 protein, but the most significant antibody production ensued following parasite oviposition. TPx-1 was localized in eggs and shown to be secreted by eggs. The identification of egg antigens is important to understand the specific basis of granuloma formation in schistosome infections and may prove to be useful in strategies to ameliorate pathological responses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.