ArticleInfection and immunity2001
Critical role for signal transducer and activator of transcription factor 6 in mediating intestinal muscle hypercontractility and worm expulsion in Trichinella spiralis-infected mice.
Article in Infection and immunity, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 85 citations in OpenAlex.
- Sex differences inProceedings of the National Academy of Sciences of the United States of America · 2026Article
- The Role of Inflammatory Mediators in the Development of Gastrointestinal Motility Disorders.International journal of molecular sciences · 2022Review
- Review
- TGFβ-activation by dendritic cells drives Th17 induction and intestinal contractility and augments the expulsion of the parasite Trichinella spiralis in mice.PLoS pathogens · 2019Article
- The DH31/CGRP enteroendocrine peptide triggers intestinal contractions favoring the elimination of opportunistic bacteria.PLoS pathogens · 2018Article
- Immune responses in mice vaccinated with a DNA vaccine expressing serine protease-like protein from the new-born larval stage of Trichinella spiralis.Parasitology · 2017Article
- Increased intestinal epithelial cell turnover and intestinal motility in Gymnophalloides seoi-infected C57BL/6 mice.The Korean journal of parasitology · 2014Article
- Involvement of interleukin-17A-induced hypercontractility of intestinal smooth muscle cells in persistent gut motor dysfunction.PloS one · 2014Article
- Signal transducer and activator of transcription factor 6 signaling contributes to control host lung pathology but favors susceptibility against Toxocara canis infection.BioMed research international · 2013Article
- Trichuris muris: a model of gastrointestinal parasite infection.Seminars in immunopathology · 2012Review
- Cytokine-induced alterations of gastrointestinal motility in gastrointestinal disorders.World journal of gastrointestinal pathophysiology · 2011Article
- Development of cellular immune response of mice to infection with low doses of Trichinella spiralis, Trichinella britovi and Trichinella pseudospiralis larvae.Parasitology research · 2011Article
- Signal Transducers and Activators of Transcription (STAT) family members in helminth infections.International journal of biological sciences · 2011Review
- Role of enteric nerves in immune-mediated changes in protease-activated receptor 2 effects on gut function.Neurogastroenterology and motility · 2010Article
- Low-grade inflammation plays a pivotal role in gastrointestinal dysfunction in irritable bowel syndrome.World journal of gastrointestinal pathophysiology · 2010Article
- CD40 and the immune response to parasitic infections.Seminars in immunology · 2009Review
- Mast cell-mediated changes in smooth muscle contractility during mouse giardiasis.Infection and immunity · 2007Article
- Gut motor function: immunological control in enteric infection and inflammation.Clinical and experimental immunology · 2006Review
- Interleukin-13: a key mediator in resistance to gastrointestinal-dwelling nematode parasites.Clinical reviews in allergy & immunology · 2004Review
- An asthma-associated genetic variant of STAT6 predicts low burden of ascaris worm infestation.Genes and immunity · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intestinal nematode infections in rats or mice are accompanied by intestinal muscle hyper contractility that may contribute to parasite expulsion from the gut. Previous studies demonstrated that both the expulsion of nematode parasites and the associated muscle hyper contractility are dependent on CD4(+) T helper cells. Nevertheless, the precise immunological mechanism underlying changes in intestinal muscle function remains to be determined. In this study, we investigated the role of interleukin 4 (IL-4) and signal transducer and activator of transcription factor 6 (STAT6) in the development of intestinal muscle hypercontractility and worm expulsion by infecting IL-4 and STAT6-deficient mice with Trichinella spiralis. Worm expulsion was almost normal in IL-4-deficient mice but substantially delayed in STAT6-deficient mice. Consistent with delayed worm expulsion, we also observed a marked attenuation of carbachol-induced muscle contraction in STAT6-deficient mice but only a moderate decrease in muscle hypercontractility in IL-4-deficient mice. In addition, we also observed severe impairment of T helper type 2 cytokine responses and intestinal mucosal mastocytosis in STAT6-deficient mice, although some degree of intestinal tissue eosinophilia was evident in these animals. These results are consistent with the hypothesis that STAT6-dependent changes in intestinal muscle function contribute to host protection in nematode infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.