ArticleInfection and immunity2001
Interleukin-6 deficiency increases inflammatory bone destruction.
Article in Infection and immunity, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 122 citations in OpenAlex.
- Therapeutic Irrigant Procedures for Treating Apical Periodontitis (TIPTAP): A triple-blinded parallel-group randomized controlled phase I/II trial.International endodontic journal · 2025Trial
- Effects of periodontal therapy on GCF cytokines in generalized aggressive periodontitis subjects.Journal of clinical periodontology · 2012Trial
- Calprotectin as a Biomarker for Infectious Diseases: A Comparative Review with Conventional Inflammatory Markers.International journal of molecular sciences · 2025Review
- Inflammatory mediators' essence in apical periodontitis.European oral research · 2024Article
- Effects of adjacent periodontitis on osseointegrated dental implants.Journal of periodontal & implant science · 2024Article
- Antimicrobial, Cytotoxic, and Anti-Inflammatory Activities ofPlants (Basel, Switzerland) · 2023Article
- Neutralization of Staphylococcus aureus Protein A Prevents Exacerbated Osteoclast Activity and Bone Loss during Osteomyelitis.Antimicrobial agents and chemotherapy · 2023Article
- Revisiting the role of IL-1 signaling in the development of apical periodontitis.Frontiers in dental medicine · 2022Article
- The inflammatory signalling mediator TAK1 mediates lymphocyte recruitment to lipopolysaccharide-activated murine mesenchymal stem cells through interleukin-6.Molecular and cellular biochemistry · 2021Article
- Re-Programming Autoreactive T Cells Into T-Regulatory Type 1 Cells for the Treatment of Autoimmunity.Frontiers in immunology · 2021Review
- Tocilizumab, a Potent Interleukin-6 Receptor Inhibitor, Decreases Bone Resorption and Increases the Rate of Bacterial Infection After Tooth Extraction in Rats.Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons · 2020Article
- Metabolomic Profiling of the Immune Stimulatory Effect of Eicosenoids on PMA-Differentiated THP-1 Cells.Vaccines · 2019Article
- Influence of static forces on the expression of selected parameters of inflammation in periodontal ligament cells and alveolar bone cells in a co-culture in vitro model.Clinical oral investigations · 2019Article
- Estimation of Sialic Acid and IL10 Levels in Stage 1 and 2 Periodontitis Patients.International journal of dentistry · 2019Article
- Pro-inflammatory and anti-inflammatory cytokine expression in post-treatment apical periodontitis.Journal of applied oral science : revista FOB · 2018Article
- Activation of hypoxia-inducible factor 1 attenuates periapical inflammation and bone loss.International journal of oral science · 2018Article
- Epigenetic gene regulation by histone demethylases: emerging role in oncogenesis and inflammation.Oral diseases · 2017Review
- Potassium is a key signal in host-microbiome dysbiosis in periodontitis.PLoS pathogens · 2017Article
- Modulation of infection-mediated migration of neutrophils and CXCR2 trafficking by osteopontin.Immunology · 2017Article
- Osteoclast-Primed Foxp3+ CD8 T Cells Induce T-bet, Eomesodermin, and IFN-γ To Regulate Bone Resorption.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Periapical bone destruction occurs as a consequence of pulpal infection. In previous studies, we showed that interleukin-1 (IL-1) is the primary stimulator of bone destruction in this model. IL-6 is a pleiotropic cytokine that is induced in these infections and has both pro- and anti-inflammatory activities. In the present study, we determined the role of IL-6 in regulating IL-1 expression and bone resorption. The first molars of IL-6 knockouts (IL-6(-/-)) and wild-type mice were subjected to surgical pulp exposure and infection with a mixture of four common pulpal pathogens, including Prevotella intermedia, Fusobacterium nucleatum, Peptostreptococcus micros, and Streptococcus intermedius. Mice were killed after 21 days, and bone destruction and cytokine expression were determined. Surprisingly, bone destruction was significantly increased in IL-6(-/-) mice versus that in wild-type mice (by 30%; P < 0.001). In a second experiment, the effects of chronic (IL-6(-/-)) IL-6 deficiency and short-term IL-6 deficiency induced by in vivo antibody neutralization were determined. Both IL-6(-/-) (30%; P < 0.001) and anti-IL-6 antibody-treated mice (40%; P < 0.05) exhibited increased periapical bone resorption, compared to wild-type controls. The increased bone resorption in IL-6-deficient animals correlated with increases in osteoclast numbers, as well as with elevated expression of bone-resorptive cytokines IL-1alpha and IL-1beta, in periapical lesions and with decreased expression of the anti-inflammatory cytokine IL-10. These data demonstrate that endogenous IL-6 expression has significant anti-inflammatory effects in modulating infection-stimulated bone destruction in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.