ArticleInfection and immunity2001
Modulation of cytokine release in ex vivo-stimulated blood from borreliosis patients.
Article in Infection and immunity, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 51 citations in OpenAlex.
- Lipoprotein-dependent and -independent immune responses to spirochetal infection.Clinical and diagnostic laboratory immunology · 2005Trial
- Stimulated Immune Response by TruCultureFrontiers in cellular and infection microbiology · 2021Observational
- Comparison of spleen transcriptomes of two wild rodent species reveals differences in the immune response againstEcology and evolution · 2020Article
- Infection with the Lyme disease pathogen suppresses innate immunity in mice with diet-induced obesity.Cellular microbiology · 2017Article
- Whole Blood Cytokine Response to Local Traffic-Related Particulate Matter in Peruvian Children With and Without Asthma.Frontiers in pharmacology · 2017Article
- The Cross-Talk between Spirochetal Lipoproteins and Immunity.Frontiers in immunology · 2014Review
- Interleukin-10 (IL-10) inhibits Borrelia burgdorferi-induced IL-17 production and attenuates IL-17-mediated Lyme arthritis.Infection and immunity · 2013Article
- Article
- Interleukin-10 alters effector functions of multiple genes induced by Borrelia burgdorferi in macrophages to regulate Lyme disease inflammation.Infection and immunity · 2011Article
- Pattern of proinflammatory cytokine induction in RAW264.7 mouse macrophages is identical for virulent and attenuated Borrelia burgdorferi.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Identification of Borrelia burgdorferi ribosomal protein L25 by the phage surface display method and evaluation of the protein's value for serodiagnosis.Journal of clinical microbiology · 2006Article
- Critical evaluation of urine-based PCR assay for diagnosis of Lyme borreliosis.Clinical and diagnostic laboratory immunology · 2005Article
- Borrelia burgdorferi-induced tolerance as a model of persistence via immunosuppression.Infection and immunity · 2003Article
- Autocrine and exocrine regulation of interleukin-10 production in THP-1 cells stimulated with Borrelia burgdorferi lipoproteins.Infection and immunity · 2002Article
- Distribution of clinically relevant Borrelia genospecies in ticks assessed by a novel, single-run, real-time PCR.Journal of clinical microbiology · 2002Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In lipopolysaccharide-stimulated blood from 71 late-stage borreliosis patients, the ex vivo cytokine release capacity of tumor necrosis factor alpha (TNF-alpha) and gamma interferon (IFN-gamma) was reduced to 28% +/- 5% and to 31% +/- 5% (P < or = 0.001), respectively, compared to that of 24 healthy controls. White blood cell counts were normal in both groups. To investigate direct interactions between the pathogen and the immune cells, blood from healthy controls was exposed in vitro to live or heat-killed Borrelia or to Borrelia lysate. Compared to the pattern induced by bacterial endotoxins, a reduced release of TNF-alpha and IFN-gamma and an enhanced secretion of interleukin-10 and granulocyte colony-stimulating factor was found. In blood from 10 borreliosis patients stimulated with Borrelia lysate, TNF-alpha formation was decreased to 31% +/- 14% and IFN-gamma formation was decreased to 8% +/- 3% (P < or = 0.001) compared to the cytokine response of blood from healthy controls (n = 24). We propose to consider anti-inflammatory changes in the blood cytokine response capacity elicited by Borrelia as a condition that might favor the persistence of the spirochete.
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