ArticleGenes & development2001
Par4 is a coactivator for a splice isoform-specific transcriptional activation domain in WT1.
Article in Genes & development, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 82 citations in OpenAlex.
- Article
- Truncated WT1 Protein Isoform Expression Is Increased in MCF-7 Cells with Long-Term Estrogen Depletion.International journal of breast cancer · 2021Article
- The transcriptional coregulatorOncotarget · 2017Article
- From General Aberrant Alternative Splicing in Cancers and Its Therapeutic Application to the Discovery of an Oncogenic DMTF1 Isoform.International journal of molecular sciences · 2017Review
- WT1 interacts with MAD2 and regulates mitotic checkpoint function.Nature communications · 2014Article
- Mechanisms of transcriptional regulation by WT1 (Wilms' tumour 1).The Biochemical journal · 2014Review
- Article
- Wt1 in the kidney--a tale in mouse models.Pediatric nephrology (Berlin, Germany) · 2014Review
- WT1/EGR1-mediated control of STIM1 expression and function in cancer cells.Frontiers in bioscience (Landmark edition) · 2011Review
- hSSB1 interacts directly with the MRN complex stimulating its recruitment to DNA double-strand breaks and its endo-nuclease activity.Nucleic acids research · 2011Article
- Transcriptional mechanisms regulating Ca(2+) homeostasis.Cell calcium · 2011Review
- AHR regulates WT1 genetic programming during murine nephrogenesis.Molecular medicine (Cambridge, Mass.) · 2011Article
- HtrA2, taming the oncogenic activities of WT1.Cell cycle (Georgetown, Tex.) · 2010Article
- Par-4: a new activator of myosin phosphatase.Molecular biology of the cell · 2010Article
- The Wilms' tumor suppressor protein WT1 is processed by the serine protease HtrA2/Omi.Molecular cell · 2010Article
- Predicting functional alternative splicing by measuring RNA selection pressure from multigenome alignments.PLoS computational biology · 2009Article
- Dynamic interaction between WT1 and BASP1 in transcriptional regulation during differentiation.Nucleic acids research · 2009Article
- ExonMiner: Web service for analysis of GeneChip Exon array data.BMC bioinformatics · 2008Article
- Down-regulation of Wilms' tumor 1 expression in glioblastoma cells increases radiosensitivity independently of p53.Journal of neuro-oncology · 2007Article
- A tumor suppressor and oncogene: the WT1 story.Leukemia · 2007Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
The Wilms' tumor suppressor protein WT1 is a transcriptional regulator involved in differentiation and the regulation of cell growth. WT1 is subject to alternative splicing, one isoform including a 17-amino acid region that is specific to mammals. The function of this 17-amino acid insertion is not clear, however. Here, we describe a transcriptional activation domain in WT1 that is specific to the WT1 splice isoform that contains the 17-amino acid insertion. We show that the function of this domain in transcriptional activation is dependent on a specific interaction with the prostate apoptosis response factor par4. A mutation in WT1 found in Wilms' tumor disturbs the interaction with par4 and disrupts the function of the activation domain. Analysis of WT1 derivatives in cells treated to induce par4 expression showed a strong correlation between the transcription function of the WT1 17-amino acid insertion and the ability of WT1 to regulate cell survival and proliferation. Our results provide a molecular mechanism by which alternative splicing of WT1 can regulate cell growth in development and disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.