ArticleThe British journal of ophthalmology2001
Clinicopathological correlation of epiretinal membranes and posterior lens opacification following perfluorohexyloctane tamponade.
Article in The British journal of ophthalmology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 80 citations in OpenAlex.
- First experiences with high-density silicone oil (Densiron) as an intraocular tamponade in complex retinal detachment.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2006Trial
- A pilot study on the use of a perfluorohexyloctane/silicone oil solution as a heavier than water internal tamponade agent.The British journal of ophthalmology · 2005Trial
- Incidence and risk factors of cataract following pediatric pars plana vitrectomy.International journal of retina and vitreous · 2025Article
- Outcomes of Heavy Silicone Oil (Densiron) compared to Silicone Oil in primary rhegmatogenous retinal detachment: a multivariable regression model.International journal of retina and vitreous · 2022Article
- Intraocular Pressure Rise Linked to Silicone Oil in Retinal Surgery: A Review.Vision (Basel, Switzerland) · 2020Review
- Risk factors for the occurrence of visual-threatening posterior capsule opacification.Journal of translational medicine · 2019Article
- Refractive results of phacoemulsification in vitrectomized patients.International ophthalmology · 2017Article
- Dealings between Cataract and Retinal Reattachment Surgery in PVR.Journal of ophthalmology · 2016Article
- Heavy silicone oil and intraocular inflammation.BioMed research international · 2014Review
- F6H8 as an Intraoperative Tool and F6H8/Silicone Oil as a Postoperative Tamponade in Inferior Retinal Detachment with Inferior PVR.Journal of ophthalmology · 2014Article
- Effect of lens status on intraocular pressure in siliconized eyes.Clinical ophthalmology (Auckland, N.Z.) · 2012Article
- Intraocular pressure changes following the use of silicone oil or Densiron 68 as endotamponade in pars plana vitrectomy.Clinical ophthalmology (Auckland, N.Z.) · 2010Article
- The use of silicone oil-RMN3 (Oxane HD) as heavier-than-water internal tamponade in complicated inferior retinal detachment surgery.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2010Article
- [Densiron-68 heavy silicone oil in cases of PVR. Anatomic and functional outcomes].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2009Article
- The concept of heavy tamponades-chances and limitations.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2008Review
- High-density silicone oil (Densiron) as a primary intraocular tamponade: 12-month follow up.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2007Article
- The combined use of perfluorohexyloctane (F6H8) and silicone oil as an intraocular tamponade in the treatment of severe retinal detachment.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2006Article
- Tamponade efficiency of perfluorohexyloctane and silicone oil solutions in a model eye chamber.The British journal of ophthalmology · 2004Article
- [Perfluorohexyloctane as internal tamponade in patients with complicated retinal detachment. Results after 6 months].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2004Article
- Tamponade properties of double-filling with perfluorohexyloctane and silicone oil in a model eye chamber.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2004Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimsEpiretinal and retrolental proliferation may occur during prolonged use of the novel tamponade agent perfluorohexyloctane (F(6)H(8)). This study aims to determine whether there is any histological evidence that F(6)H(8) has a role in the formation of these membranes.
methodsEight epiretinal membranes and three opaque posterior lens capsules were excised from patients in whom F(6)H(8) had been used as a long term retinal tamponade agent. The membranes and capsules were examined employing light microscopic methods, including immunohistochemistry.
resultsThe epiretinal membranes showed histological features typical of proliferative vitreoretinopathy (PVR) epiretinal membranes, but they also exhibited a dense macrophagic infiltration. In addition, three of the membranes contained multinucleated cells. Macrophages represented up to 30% of the cells present and appeared to contain large intracytoplasmic vacuoles. Similar cells were seen on the back of the posterior lens capsule in one specimen and all three capsules had posterior migration of lens epithelium.
conclusionThe pathological findings are not simply those of PVR. The macrophage infiltration suggests that there may be a biological reaction to F(6)H(8) which could reflect its surmised propensity to emulsify. Further investigations concerning the cellular response to this promising tamponade agent are warranted.
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