ArticleBiophysical journal2001
Calculations show substantial serial engagement of T cell receptors.
Article in Biophysical journal, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 65 citations in OpenAlex.
- Mechanical forces amplify TCR mechanotransduction in T cell activation and function.Applied physics reviews · 2024Review
- Fluctuations in T cell receptor and pMHC interactions regulate T cell activation.Journal of the Royal Society, Interface · 2022Article
- Mechanical feedback enables catch bonds to selectively stabilize scanning microvilli at T-cell surfaces.Molecular biology of the cell · 2019Article
- A cell topography-based mechanism for ligand discrimination by the T cell receptor.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Catch Bonds at T Cell Interfaces: Impact of Surface Reorganization and Membrane Fluctuations.Biophysical journal · 2017Article
- Phenotypic models of T cell activation.Nature reviews. Immunology · 2014Review
- The Serial Engagement Model 17 Years After: From TCR Triggering to Immunotherapy.Frontiers in immunology · 2012Article
- Systems biology in immunology: a computational modeling perspective.Annual review of immunology · 2011Review
- Kinetic proofreading and the search for nonself-peptides.Self/nonself · 2011Article
- A mathematical framework for analyzing T cell receptor scanning of peptides.Biophysical journal · 2010Article
- A detailed mathematical model predicts that serial engagement of IgE-Fc epsilon RI complexes can enhance Syk activation in mast cells.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Perspectives for computer modeling in the study of T cell activation.Cold Spring Harbor perspectives in biology · 2010Review
- Pairing computation with experimentation: a powerful coupling for understanding T cell signalling.Nature reviews. Immunology · 2010Review
- A role for rebinding in rapid and reliable T cell responses to antigen.PLoS computational biology · 2009Article
- Analysis of serial engagement and peptide-MHC transport in T cell receptor microclusters.Biophysical journal · 2008Article
- A model for the interplay of receptor recycling and receptor-mediated contact in T cells.PloS one · 2007Article
- Quantitative analysis of the role of receptor recycling in T cell polarization.Biophysical journal · 2006Article
- T-cell activation: A queuing theory analysis at low agonist density.Biophysical journal · 2006Article
- Frequency encoding of T-cell receptor engagement dynamics in calcium time series.Biophysical journal · 2005Article
- Effects of the geometry of the immunological synapse on the delivery of effector molecules.Biophysical journal · 2004Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
The serial engagement model provides an attractive and plausible explanation for how a typical antigen presenting cell, exhibiting a low density of peptides recognized by a T cell, can initiate T cell responses. If a single peptide displayed by a major histocompatibility complex (MHC) can bind, sequentially, to different T cell receptors (TCR), then a few peptides can activate many receptors. To date, arguments supporting and questioning the prevalence of serial engagement have centered on the down-regulation of TCR after contact of T cells with antigen presenting cells. Recently, the existence of serial engagement has been challenged by the demonstration that engagement of TCR can down-regulate nonengaged bystander TCR. Here we show that for binding and dissociation rates that characterize interactions between T cell receptors and peptide-MHC, substantial serial engagement occurs. The result is independent of mechanisms and measurements of receptor down-regulation. The conclusion that single peptide-MHC engage many TCR, before diffusing out of the contact region between the antigen-presenting cell and the T cell, is based on a general first passage time calculation for a particle alternating between states in which different diffusion coefficients govern its transport.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.