ArticleBiophysical journal2001
Kcnkø: single, cloned potassium leak channels are multi-ion pores.
Article in Biophysical journal, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Potassium channels in depression: emerging roles and potential targets.Cell & bioscience · 2024Review
- The cellular pathways that maintain the quality control and transport of diverse potassium channels.Biochimica et biophysica acta. Gene regulatory mechanisms · 2023Article
- SUMOylation silences heterodimeric TASK potassium channels containing K2P1 subunits in cerebellar granule neurons.Science signaling · 2012Article
- A Role for K2P Channels in the Operation of Somatosensory Nociceptors.Frontiers in molecular neuroscience · 2012Article
- K2P potassium channels, mysterious and paradoxically exciting.Science signaling · 2011Article
- Activator-induced dynamic disorder and molecular memory in human two-pore domain hTREK1 K channel.Journal of chemical biology · 2011Article
- One SUMO is sufficient to silence the dimeric potassium channel K2P1.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- A structural model for K2P potassium channels based on 23 pairs of interacting sites and continuum electrostatics.The Journal of general physiology · 2009Article
- The mechano-gated K(2P) channel TREK-1.European biophysics journal : EBJ · 2009Review
- Alternative translation initiation in rat brain yields K2P2.1 potassium channels permeable to sodium.Neuron · 2008Article
- Tl+-induced micros gating of current indicates instability of the MaxiK selectivity filter as caused by ion/pore interaction.The Journal of general physiology · 2008Article
- Biophysical and pharmacological characteristics of native two-pore domain TASK channels in rat adrenal glomerulosa cells.The Journal of membrane biology · 2006Article
- Intrinsic noise in cultured hippocampal neurons: experiment and modeling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- External barium affects the gating of KCNQ1 potassium channels and produces a pore block via two discrete sites.The Journal of general physiology · 2004Article
- Opening and closing of KCNKO potassium leak channels is tightly regulated.The Journal of general physiology · 2000Article
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Authors and funding
2 authors.
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Abstract
KCNKØ was the first clone to show attributes of a leak conductance: voltage-independent potassium currents that develop without delay. Its novel product is predicted to have two nonidentical P domains and four transmembrane segments and to assemble in pairs. Here, the mechanistic basis for leak is examined at the single-channel level. KCNKØ channels open at all voltages in bursts that last for minutes with open probability close to 1. The channels also enter a minutes-long closed state in a tightly regulated fashion. KCNKØ has a common relative permeability series (Eisenman type IV) but conducts only thallium and potassium readily. KCNKØ exhibits concentration-dependent unitary conductance, anomalous mole fraction behavior, and pore occlusion by barium. These observations argue for ion-channel and ion-ion interactions in a multi-ion pore and deny the operation of independence or constant-field current formulations. Despite their unique function and structure, leakage channels are observed to operate like classical potassium channels formed with one-P-domain subunits.
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