ArticleBiophysical journal2001
A preferred amplitude of calcium sparks in skeletal muscle.
Article in Biophysical journal, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed.
- Correlation of Phenotype-Genotype and Protein Structure inFrontiers in neurology · 2022Article
- Calcium-induced release of calcium in muscle: 50 years of work and the emerging consensus.The Journal of general physiology · 2018Review
- Isoproterenol increases the fraction of spark-dependent RyR-mediated leak in ventricular myocytes.Biophysical journal · 2013Article
- Properties of Ca2+ sparks revealed by four-dimensional confocal imaging of cardiac muscle.The Journal of general physiology · 2012Article
- Ca sparks do not explain all ryanodine receptor-mediated SR Ca leak in mouse ventricular myocytes.Biophysical journal · 2010Article
- Article
- Modulation of the local SR Ca2+ release by intracellular Mg2+ in cardiac myocytes.The Journal of general physiology · 2008Article
- Calcium-dependent inactivation terminates calcium release in skeletal muscle of amphibians.The Journal of general physiology · 2008Article
- Kinetics of calcium spikes in rat cardiac myocytes.The Journal of physiology · 2007Article
- Mini-dystrophin expression down-regulates IP3-mediated calcium release events in resting dystrophin-deficient muscle cells.The Journal of general physiology · 2006Article
- The changes in Ca2+ sparks associated with measured modifications of intra-store Ca2+ concentration in skeletal muscle.The Journal of general physiology · 2006Article
- Automated detection of elementary calcium release events using the á trous wavelet transform.Biophysical journal · 2006Article
- Elementary Ca2+ release events in mammalian skeletal muscle: effects of the anaesthetic drug thiopental.Journal of muscle research and cell motility · 2006Article
- The elusive role of store depletion in the control of intracellular calcium release.Journal of muscle research and cell motility · 2006Review
- Ca2+ sparks and secretion in dorsal root ganglion neurons.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Regulation of Ca2+ sparks by Ca2+ and Mg2+ in mammalian and amphibian muscle. An RyR isoform-specific role in excitation-contraction coupling?The Journal of general physiology · 2004Article
- The elementary events of Ca2+ release elicited by membrane depolarization in mammalian muscle.The Journal of physiology · 2004Article
- Polymorphism of Ca2+ sparks evoked from in-focus Ca2+ release units in cardiac myocytes.Biophysical journal · 2004Article
- Crosstalk between ryanodine receptors and IP(3) receptors as a factor shaping spontaneous Ca(2+)-release events in rabbit portal vein myocytes.The Journal of physiology · 2002Article
- Stochastic properties of Ca(2+) release of inositol 1,4,5-trisphosphate receptor clusters.Biophysical journal · 2002Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
In skeletal and cardiac muscle, calcium release from the sarcoplasmic reticulum, leading to contraction, often results in calcium sparks. Because sparks are recorded by confocal microscopy in line-scanning mode, their measured amplitude depends on their true amplitude and the position of the spark relative to the scanned line. We present a method to derive from measured amplitude histograms the actual distribution of spark amplitudes. The method worked well when tested on simulated distributions of experimental sparks. Applied to massive numbers of sparks imaged in frog skeletal muscle under voltage clamp in reference conditions, the method yielded either a decaying amplitude distribution (6 cells) or one with a central mode (5 cells). Caffeine at 0.5 or 1 mM reversibly enhanced this mode (5 cells) or induced its appearance (4 cells). The occurrence of a mode in the amplitude distribution was highly correlated with the presence of a mode in the distribution of spark rise times or in the joint distribution of rise times and spatial widths. If sparks were produced by individual Markovian release channels evolving reversibly, they should not have a preferred rise time or amplitude. Channel groups, instead, could cooperate allosterically or through their calcium sensitivity, and give rise to a stereotyped amplitude in their collective spark.
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Registered trials
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