ArticleBiophysical journal2001
Intercellular Ca2+ wave propagation through gap-junctional Ca2+ diffusion: a theoretical study.
Article in Biophysical journal, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Calcium Buffering in Astrocytes and Its Relevance for Experimental Data Interpretation and Computational Modeling.Journal of neurochemistry · 2026Review
- A complete biomechanical model ofProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Analysis of localized cAMP perturbations within a tissue reveal the effects of a local, dynamic gap junction state on ERK signaling.PLoS computational biology · 2022Article
- Calcium Signaling in the Photodamaged Skin: In Vivo Experiments and Mathematical Modeling.Function (Oxford, England) · 2022Article
- Calcium mediated functional interplay between myocardial cells upon laser-induced single-cell injury: an in vitro study of cardiac cell death signaling mechanisms.Cell communication and signaling : CCS · 2020Article
- Ultrasensitive gold micro-structured electrodes enabling the detection of extra-cellular long-lasting potentials in astrocytes populations.Scientific reports · 2017Article
- A model of auto immune response.BMC immunology · 2017Article
- Wound-induced CaMolecular biology of the cell · 2017Article
- Calcium dynamics and regulation in horizontal cells of the vertebrate retina: lessons from teleosts.Journal of neurophysiology · 2017Review
- Reproducibility and Comparability of Computational Models for Astrocyte Calcium Excitability.Frontiers in neuroinformatics · 2017Article
- Intercellular ultrafast Ca(2+) wave in vascular smooth muscle cells: numerical and experimental study.Scientific reports · 2016Article
- Low pH enhances connexin32 degradation in the pancreatic acinar cell.American journal of physiology. Gastrointestinal and liver physiology · 2014Article
- Intercellular Ca(2+) waves: mechanisms and function.Physiological reviews · 2012Review
- Mechanisms of propagation of intercellular calcium waves in arterial smooth muscle cells.Biophysical journal · 2010Article
- Connexin specificity of second messenger permeation: real numbers at last.The Journal of general physiology · 2008Article
- Pacemaking through Ca2+ stores interacting as coupled oscillators via membrane depolarization.Biophysical journal · 2007Article
- A stochastic two-dimensional model of intercellular Ca2+ wave spread in glia.Biophysical journal · 2006Article
- Calcium oscillations in a triplet of pancreatic acinar cells.Biophysical journal · 2005Article
- Ca2+ dynamics in a population of smooth muscle cells: modeling the recruitment and synchronization.Biophysical journal · 2004Article
- Role of sarcoplasmic reticulum and mitochondria in Ca2+ removal in airway myocytes.Biophysical journal · 2004Article
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Authors and funding
3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Intercellular regenerative calcium waves in systems such as the liver and the blowfly salivary gland have been hypothesized to spread through calcium-induced calcium release (CICR) and gap-junctional calcium diffusion. A simple mathematical model of this mechanism is developed. It includes CICR and calcium removal from the cytoplasm, cytoplasmic and gap-junctional calcium diffusion, and calcium buffering. For a piecewise linear approximation of the calcium kinetics, expressions in terms of the cellular parameters are derived for 1) the condition for the propagation of intercellular waves, and 2) the characteristic time of the delay of a wave encountered at the gap junctions. Intercellular propagation relies on the local excitation of CICR in the perijunctional space by gap-junctional calcium influx. This mechanism is compatible with low effective calcium diffusivity, and necessitates that CICR can be excited in every cell along the path of a wave. The gap-junctional calcium permeability required for intercellular waves in the model falls in the range of reported gap-junctional permeability values. The concentration of diffusive cytoplasmic calcium buffers and the maximal rate of CICR, in the case of inositol 1,4,5-trisphosphate (IP3) receptor calcium release channels set by the IP(3) concentration, are shown to be further determinants of wave behavior.
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