ArticleBiophysical journal2001
Models of motor-assisted transport of intracellular particles.
Article in Biophysical journal, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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Who cites it
57 citing papers in PubMed, 178 citations in OpenAlex.
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- Increasing the accuracy of single-molecule data analysis using tMAVEN.Biophysical journal · 2024Article
- Increasing the accuracy of single-molecule data analysis using tMAVEN.bioRxiv : the preprint server for biology · 2024Article
- Trafficking in cancer: from gene deregulation to altered organelles and emerging biophysical properties.Frontiers in cell and developmental biology · 2024Review
- The interplay of active and passive mechanisms in slow axonal transport.Biophysical journal · 2023Article
- Modeling material transport regulation and traffic jam in neurons using PDE-constrained optimization.Scientific reports · 2022Article
- Can the lack of fibrillar form of alpha-synuclein in Lewy bodies be explained by its catalytic activity?Mathematical biosciences · 2022Article
- Mathematical models of neuronal growth.Biomechanics and modeling in mechanobiology · 2022Review
- Spatial redistribution of neurosecretory vesicles upon stimulation accelerates their directed transport to the plasma membrane.PloS one · 2022Article
- Paradoxical relationships between active transport and global protein distributions in neurons.Biophysical journal · 2021Article
- Deep learning of material transport in complex neurite networks.Scientific reports · 2021Article
- Modelling the motion of organelles in an elongated cell via the coordination of heterogeneous drift-diffusion and long-range transport.The European physical journal. E, Soft matter · 2021Article
- Quasi-steady-state reduction of a model for cytoplasmic transport of secretory vesicles in stimulated chromaffin cells.Journal of mathematical biology · 2021Article
- Statistical Laws of Protein Motion in Neuronal Dendritic Trees.Cell reports · 2020Article
- Crowd Control: Effects of Physical Crowding on Cargo Movement in Healthy and Diseased Neurons.Frontiers in cellular neuroscience · 2019Review
- Simulating the effect of formation of amyloid plaques on aggregation of tau protein.Proceedings. Mathematical, physical, and engineering sciences · 2018Article
- A mathematical understanding of how cytoplasmic dynein walks on microtubules.Royal Society open science · 2018Article
- How the formation of amyloid plaques and neurofibrillary tangles may be related: a mathematical modelling study.Proceedings. Mathematical, physical, and engineering sciences · 2018Article
- Mathematical modeling and quantitative analysis of HIV-1 Gag trafficking and polymerization.PLoS computational biology · 2017Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
One-dimensional models are presented for the macroscopic intracellular transport of vesicles and organelles by molecular motors on a network of aligned intracellular filaments. A motor-coated vesicle or organelle is described as a diffusing particle binding intermittently to filaments, when it is transported at the motor velocity. Two models are treated in detail: 1) a unidirectional model, where only one kind of motor is operative and all filaments have the same polarity; and 2) a bidirectional model, in which filaments of both polarities exist (for example, a randomly polarized actin network for myosin motors) and/or particles have plus-end and minus-end motors operating on unipolar filaments (kinesin and dynein on microtubules). The unidirectional model provides net particle transport in the absence of a concentration gradient. A symmetric bidirectional model, with equal mixtures of filament polarities or plus-end and minus-end motors of the same characteristics, provides rapid transport down a concentration gradient and enhanced dispersion of particles from a point source by motor-assisted diffusion. Both models are studied in detail as a function of the diffusion constant and motor velocity of bound particles, and their rates of binding to and detachment from filaments. These models can form the basis of more realistic models for particle transport in axons, melanophores, and the dendritic arms of melanocytes, in which networks of actin filaments and microtubules coexist and motors for both types of filament are implicated.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.