ArticleBiophysical journal2001
Underlying mechanisms of symmetric calcium wave propagation in rat ventricular myocytes.
Article in Biophysical journal, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 48 citations in OpenAlex.
- A stochastic mathematical model for coupling the cytosolic and sarcoplasmic calcium movements in diseased cardiac myocytes.European biophysics journal : EBJ · 2022Article
- Estimating the probabilities of rare arrhythmic events in multiscale computational models of cardiac cells and tissue.PLoS computational biology · 2017Article
- Distribution and Function of Cardiac Ryanodine Receptor Clusters in Live Ventricular Myocytes.The Journal of biological chemistry · 2015Article
- Ryanodine receptor gating controls generation of diastolic calcium waves in cardiac myocytes.The Journal of general physiology · 2015Article
- Hierarchical clustering of ryanodine receptors enables emergence of a calcium clock in sinoatrial node cells.The Journal of general physiology · 2014Article
- Ca²⁺ waves in the heart.Journal of molecular and cellular cardiology · 2013Review
- Mitochondrial Ca²⁺ homeostasis: mechanism, role, and tissue specificities.Pflugers Archiv : European journal of physiology · 2012Review
- Gain of function of cardiac ryanodine receptor in a rat model of type 1 diabetes.Cardiovascular research · 2011Article
- A mathematical model of spontaneous calcium release in cardiac myocytes.American journal of physiology. Heart and circulatory physiology · 2011Article
- Axial tubules of rat ventricular myocytes form multiple junctions with the sarcoplasmic reticulum.Biophysical journal · 2009Article
- Distribution of ryanodine receptors in rat ventricular myocytes.Journal of muscle research and cell motility · 2009Article
- Measurement and modeling of Ca2+ waves in isolated rabbit ventricular cardiomyocytes.Biophysical journal · 2007Article
- Functional groups of ryanodine receptors in rat ventricular cells.The Journal of physiology · 2007Article
- Mechanisms of sudden cardiac death.The Journal of clinical investigation · 2005Review
- Disposition of calcium release units in agarose gel for an optimal propagation of Ca2+ signals.Biophysical journal · 2004Article
- Over-expression of FK506-binding protein FKBP12.6 alters excitation-contraction coupling in adult rabbit cardiomyocytes.The Journal of physiology · 2004Article
- A comparison of the effects of ATP and tetracaine on spontaneous Ca(2+) release from rat permeabilised cardiac myocytes.The Journal of physiology · 2001Article
- Estimation of stochastic behaviour in cardiac myocytes: I. CaJRSM cardiovascular diseaseArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Calcium waves in heart cells are mediated by diffusion-coupled calcium-induced calcium release. The waves propagate in circular fashion. This is counterintuitive in view of the accepted ultrastructure of the cardiac myocyte. The density of calcium release sites in the transverse direction is four times higher than in the longitudinal direction. Simulations with release sites localized along Z-lines and isotropic diffusion yielded highly elliptical, nonphysiological waves. We hypothesized that subcellular organelles counteracted the higher release site density along the Z-lines by acting as transverse diffusion barriers and sites of active calcium uptake. We quantified the reduction of transverse diffusion by microinjecting cells with the nonreactive dye fluorescein. The ratio of the radial diffusion coefficient to the longitudinal coefficient was 0.39. Inhibition of mitochondrial uptake by rotenone accelerated the wave in the transverse direction. Simulations with release sites clustered at the Z-lines and a transverse diffusion coefficient 50% of the longitudinal coefficient generated waves of ellipticity 2/1 (major axis along the Z-line). Introducing additional release sites between the Z-lines at a density 20% of that on the Z-lines produced circular waves. The experiments and simulations support the presence of transverse diffusion barriers, additional uptake sites, and possibly intermediate release sites as well.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.