Trial reportArchives of disease in childhood2001
Randomised controlled study of clinical efficacy of spacer therapy in asthma with regard to electrostatic charge.
Trial report in Archives of disease in childhood, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 38 citations in OpenAlex.
- Response to albuterol MDI delivered through an anti-static chamber during nocturnal bronchospasm.Respiratory care · 2012Trial
- Optimal administration of bronchodilators with valved holding chambers in preschool children: a review of literature.European journal of pediatrics · 2021Review
- A path to successful patient outcomes through aerosol drug delivery to children: a narrative review.Annals of translational medicine · 2021Review
- Treating COPD Patients with Inhaled Medications in the Era of COVID-19 and Beyond: Options and Rationales for Patients at Home.International journal of chronic obstructive pulmonary disease · 2021Review
- Drug delivery interfaces: A way to optimize inhalation therapy in spontaneously breathing children.World journal of clinical pediatrics · 2016Review
- Aerosol profile extracted from spacers as a determinant of actual dose.Pharmaceutical research · 2004Article
- The use of inhaled corticosteroids in children with asthma.Current allergy and asthma reports · 2002Review
- A review of the in vitro and in vivo valved holding chamber (VHC) literature with a focus on the AeroChamber Plus Flow-Vu Anti-static VHC.Therapeutic advances in respiratory diseaseReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInhalation therapy using a pressured metered dose inhaler (pMDI) and a spacer is frequently used in the treatment of airway disease in children. Several laboratory studies found a clear negative influence of electrostatic charge (ESC) on plastic spacers on the delivery of aerosol.
aimsTo investigate whether ESC on plastic spacers could diminish bronchodilating responses to salbutamol.
methodsNinety asthmatic children (aged 4-8 years) were randomised into three groups: metal Nebuchamber, plastic Volumatic, and plastic Aerochamber. The bronchodilating response was measured by the change in peak expiratory flow rate (PEF) after 100 microgram and 400 microgram salbutamol. Within the Volumatic and Aerochamber groups, a crossover comparison was made between electrostatic and non-electrostatic spacers.
resultsWe found no significant effect of ESC on the bronchodilating response to salbutamol with any of the doses in the Aerochamber and Volumatic groups. For the plastic spacers, the mean difference of the change in PEF after 100 microgram salbutamol between non-electrostatic and electrostatic spacers was only +1.7% (95% CI -1.3% to 4.7%). After 400 microgram salbutamol this was +1.9% (95% CI -1.4% to 5.1%). A comparable efficacy was found for the Nebuchamber, the Aerochamber, and Volumatic with respect to the change in PEF after 100 and 400 microgram salbutamol.
conclusionThis study showed no negative influence of ESC on plastic spacers with regard to clinical efficacy of a beta(2) agonist (salbutamol) in children with asthma. The metal Nebuchamber, plastic Aerochamber, and plastic Volumatic were equally effective.
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