ArticleThe American journal of pathology2001
Massive liver replacement by transplanted hepatocytes in the absence of exogenous growth stimuli in rats treated with retrorsine.
Article in The American journal of pathology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 95 citations in OpenAlex.
- Cell competition in liver carcinogenesis.World journal of hepatology · 2020Review
- Evidence of Amniotic Epithelial Cell Differentiation toward Hepatic Sinusoidal Endothelial Cells.Cell transplantation · 2018Article
- Unravelling the immunological roles of dipeptidyl peptidase 4 (DPP4) activity and/or structure homologue (DASH) proteins.Clinical and experimental immunology · 2016Review
- Ischemic preconditioning affects long-term cell fate through DNA damage-related molecular signaling and altered proliferation.The American journal of pathology · 2014Article
- Non-viral FoxM1 gene delivery to hepatocytes enhances liver repopulation.Cell death & disease · 2014Article
- Cell turnover in the repopulated rat liver: distinct lineages for hepatocytes and the biliary epithelium.Cell and tissue research · 2014Article
- Article
- Disappearance of GFP-positive hepatocytes transplanted into the liver of syngeneic wild-type rats pretreated with retrorsine.PloS one · 2014Article
- Molecular perturbations restrict potential for liver repopulation of hepatocytes isolated from non-heart-beating donor rats.Hepatology (Baltimore, Md.) · 2012Article
- The nude mouse as model for liver deficiency study and treatment and xenotransplantation.International journal of hepatology · 2012Article
- The growth pattern of transplanted normal and nodular hepatocytes.Histochemistry and cell biology · 2011Article
- Liver regeneration: alternative epithelial pathways.The international journal of biochemistry & cell biology · 2011Review
- Model systems and experimental conditions that lead to effective repopulation of the liver by transplanted cells.The international journal of biochemistry & cell biology · 2011Review
- RNA interference against hepatic epidermal growth factor receptor has suppressive effects on liver regeneration in rats.The American journal of pathology · 2010Article
- The generation of hepatocytes from mesenchymal stem cells and engraftment into murine liver.Nature protocols · 2010Article
- Stem cell therapy for inherited metabolic disorders of the liver.Experimental hematology · 2008Review
- Proliferation of L02 human hepatocytes in tolerized genetically immunocompetent rats.World journal of gastroenterology · 2008Article
- Liver repopulation and carcinogenesis: two sides of the same coin?The American journal of pathology · 2008Review
- Persistence of a chimerical phenotype after hepatocyte differentiation of human bone marrow mesenchymal stem cells.Cell proliferation · 2008Article
- Immunohistochemical characterization of hepatic stem cell-related cells in developing human liver.Frontiers of medicine in China · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
A strategy for hepatocyte transplantation was recently developed whereby massive replacement of the recipient liver is achieved after a combined treatment with retrorsine, a pyrrolizidine alkaloid, and partial hepatectomy. We now investigated whether liver repopulation could occur in this animal model in the absence of any exogenous growth stimuli (eg, partial hepatectomy) for the transplanted cells. Dipeptidyl-peptidase type IV-deficient (DPPIV-) rats were used as recipients. Rats were given two injections of retrorsine (30 mg/kg each, 2 weeks apart), followed by transplantation of 2 x 10(6) hepatocytes isolated from a normal, syngeneic, DPPIV+ donor. At 2 weeks after transplantation, clusters of DPPIV+ hepatocytes occupied 3.3 +/- 0.9% of host liver, increasing to 38.2 +/- 6.3% at 2 months, and to 65.9 +/- 8.8% at 5 months. By 1 year, >95% of the original hepatocytes were replaced by donor-derived cells. Serum parameters related both to hepatocyte function and integrity (including glucose, bilirubin, total proteins, cholinesterase, alanine aminotransferase, and alkaline phosphatase) were in the normal range in retrorsine-treated and repopulated animals. These results provide further insights toward developing strategies for effective liver repopulation by transplanted hepatocytes with reduced toxicity for the host and potential clinical applicability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.