ArticleThe American journal of pathology2001
Localization of the peptide transporter PEPT2 in the lung: implications for pulmonary oligopeptide uptake.
Article in The American journal of pathology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 146 citations in OpenAlex.
- Integrative analysis and experimental validation of dioxin-interacting genes reveal diagnostic and prognostic biomarkers in lung adenocarcinoma.Clinical and experimental medicine · 2026Article
- Considerations for Carnosine Actions in Biology.Neurochemical research · 2026Review
- Transporters and drug secretion into human breast milk.Expert opinion on drug metabolism & toxicology · 2025Review
- Transporter-Mediated Drug Delivery.Molecules (Basel, Switzerland) · 2023Review
- Biology of Peptide Transporter 2 in Mammals: New Insights into Its Function, Structure and Regulation.Cells · 2022Review
- Small Airway Susceptibility to Chemical and Particle Injury.Respiration; international review of thoracic diseases · 2022Review
- A mechanism for matrikine regulation in acute inflammatory lung injury.JCI insight · 2021Article
- Identification of PEPT2 as an important candidate molecule in 5-ALA-mediated fluorescence-guided surgery in WHO grade II/III gliomas.Journal of neuro-oncology · 2019Article
- Oligopeptide Transport in Rat Lung Alveolar Epithelial Cells is Mediated by Pept2.Pharmaceutical research · 2017Article
- Pulmonary Pharmacokinetics of Colistin following Administration of Dry Powder Aerosols in Rats.Antimicrobial agents and chemotherapy · 2017Article
- Functional Expression of PEPT2 in the Human Distal Lung Epithelial Cell Line NCl-H441.Pharmaceutical research · 2015Article
- The di-peptide Trp-His activates AMP-activated protein kinase and enhances glucose uptake independently of insulin in L6 myotubes.FEBS open bio · 2014Article
- Functional and molecular expression of the proton-coupled oligopeptide transporters in spleen and macrophages from mouse and human.Molecular pharmaceutics · 2013Article
- Effect of cigarette smoke extract on insulin transport in alveolar epithelial cell line A549.Lung · 2012Article
- Expression Profile of Drug and Nutrient Absorption Related Genes in Madin-Darby Canine Kidney (MDCK) Cells Grown under Differentiation Conditions.Pharmaceutics · 2012Article
- Pulmonary drug delivery strategies: A concise, systematic review.Lung India : official organ of Indian Chest Society · 2012Article
- Immunocytochemistry for bestatin and its application to drug accumulation studies in rat intestine and kidney.Journal of molecular histology · 2011Article
- Transport rather than diffusion-dependent route for nitric oxide gas activity in alveolar epithelium.Free radical biology & medicine · 2010Article
- Xenobiotic, bile acid, and cholesterol transporters: function and regulation.Pharmacological reviews · 2010Review
- Bacterial peptide recognition and immune activation facilitated by human peptide transporter PEPT2.American journal of respiratory cell and molecular biology · 2008Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pulmonary delivery of peptidomimetic antibiotics is frequently used for local drug therapy in pulmonary infections. Identification of transport pathways into airway epithelia can lead to new strategies of therapy. Here we describe the distribution of the beta-lactam-transporting high-affinity proton-coupled peptide transporter PEPT2 in mammalian lungs. Using reverse transcriptase-polymerase chain reaction and Northern blot analysis, PEPT2-mRNA was detected in lung extracts. The expression of PEPT2-mRNA and protein was localized to alveolar type II pneumocytes, bronchial epithelium, and endothelium of small arteries of rat lung by nonisotopic in situ hybridization and immunohistochemistry. In addition, transport studies using murine whole-organ preparations revealed transporter-mediated uptake of a fluorophore-conjugated dipeptide derivative into bronchial epithelial cells and type II pneumocytes. This transport was competitively inhibited by cephalosporins and dipeptides that are reported as PEPT2-carried substrates. Cell specificity of the PEPT2-mediated uptake pattern was confirmed by double labeling with Lycopersicon esculentum lectin. Together these data suggest that PEPT2 is the molecular basis for the transport of peptides and peptidomimetics in pulmonary epithelial cells. In conclusion PEPT2 may be an interesting target for pulmonary delivery of peptides and peptidomimetics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.