ArticleThe American journal of pathology2001
API2-MALT1 fusion transcripts involved in mucosa-associated lymphoid tissue lymphoma: multiplex RT-PCR detection using formalin-fixed paraffin-embedded specimens.
Article in The American journal of pathology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 104 citations in OpenAlex.
- Clinicopathological significance of CD28 overexpression in adult T-cell leukemia/lymphoma.Cancer science · 2022Article
- Clinical significance of CD28 gene-related activating alterations in adult T-cell leukaemia/lymphoma.British journal of haematology · 2021Article
- Achromobacter Infection Is Rare in Japanese Patients with Pulmonary B-cell Lymphoma.Internal medicine (Tokyo, Japan) · 2018Article
- Novel developments in the pathogenesis and diagnosis of extranodal marginal zone lymphoma.Journal of hematopathology · 2017Review
- First-line antibiotic therapy in Helicobacter pylori-negative low-grade gastric mucosa-associated lymphoid tissue lymphoma.Scientific reports · 2017Article
- Cellular-level characterization of B cells infiltrating pulmonary MALT lymphoma tissues.Virchows Archiv : an international journal of pathology · 2016Article
- Successful treatment of mucosa-associated lymphoid tissue lymphoma in a patient with gastric and rectal lesions with metachronous and ectopic development.Rare tumors · 2011Article
- Marginal zone lymphomas involving meningeal dura: possible link to IgG4-related diseases.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2011Article
- t (11;18)(q21;q21) chromosome translocation (A1446-M1150) of MALT lymphoma in buccal mucosa.Journal of cancer research and clinical oncology · 2010Article
- Marginal zone lymphomas in children and the young adult population; characterization of genetic aberrations by FISH and RT-PCR.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2010Article
- Translocation t(11;18)(q21;q21) in gastric B-cell lymphomas.Cancer science · 2009Article
- Significance of CXCR3 expression in gastric low-grade B-cell lymphoma of mucosa-associated lymphoid tissue type for predicting responsiveness to Helicobacter pylori eradication.Cancer science · 2008Article
- Article
- Update on extranodal lymphomas. Conclusions of the Workshop held by the EAHP and the SH in Thessaloniki, Greece.Histopathology · 2006Review
- Melanoma inhibitor of apoptosis protein is expressed differentially in melanoma and melanocytic naevus, but similarly in primary and metastatic melanomas.Journal of clinical pathology · 2005Article
- Detection of API2-MALT1 fusion transcripts in cytologic specimens of patients with pulmonary mucosa-associated lymphoid tissue lymphoma.International journal of hematology · 2005Article
- T(3;14)(p14.1;q32) involving IGH and FOXP1 is a novel recurrent chromosomal aberration in MALT lymphoma.Leukemia · 2005Article
- Trisomy 3 may predict a poor response of gastric MALT lymphoma to Helicobacter pylori eradication therapy.World journal of gastroenterology · 2005Article
- Variable frequencies of MALT lymphoma-associated genetic aberrations in MALT lymphomas of different sites.Leukemia · 2004Article
- Unfavourable prognosis of patients with trisomy 18q21 detected by fluorescence in situ hybridisation in t(11;18) negative, surgically resected, gastrointestinal B cell lymphomas.Journal of clinical pathology · 2004Article
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Authors and funding
6 authors at 2 institutions in 1 country.
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Abstract
Malignant lymphoma of mucosa-associated lymphoid tissue (MALT) type is a distinct clinicopathological disease entity in the category of extranodal marginal zone B-cell lymphoma. Recently, we and others have shown that the API2 gene on chromosome 11 and the MALT1 gene on chromosome 18 are fused as a result of t(11;18)(q21;q21) in MALT lymphomas. Here we report a detection assay that can be used for formalin-fixed, paraffin-embedded specimens. It consists of a multiplex one-tube reverse transcriptase-polymerase chain reaction (RT-PCR) followed by three parallel multiplex nested polymerase chain reactions. Eight variants of the fusion transcripts have been reported to date. When these variants were used as positive controls, all were successfully detected. The subsequent direct sequencing confirmed the results. Using this rapid and simple method, we could detect API2-MALT1 fusion transcripts in 5 of 15 (33%) archival cases of MALT lymphoma for a frequency comparable with those of RT-PCR assays using frozen materials. The lung was the preferential anatomical site of origin of MALT lymphomas harboring API2-MALT1 fusion. No fusion transcript was detected in any of 20 high-grade B-cell lymphomas. Our multiplex RT-PCR assay, which can be used for routinely-processed paraffin samples, should serve as a useful molecular tool for clarifying the clinicopathological significance of API2-MALT1 fusion in MALT lymphoma.
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