ArticleThe American journal of pathology2001
Mucosal pathophysiology and inflammatory changes in the late phase of the intestinal allergic reaction in the rat.
Article in The American journal of pathology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 76 citations in OpenAlex.
- Antigenicity evaluation of lac color and exploratory study for identifying potential biomarkers of anaphylaxis.Laboratory animal research · 2024Article
- Article
- Biphasic and protracted anaphylaxis to iodinated contrast media.European radiology · 2018Observational
- Gastrointestinal dysfunction in autism spectrum disorder: the role of the mitochondria and the enteric microbiome.Microbial ecology in health and disease · 2015Article
- Staphylococcal enterotoxin B suppresses Alix and compromises intestinal epithelial barrier functions.Journal of biomedical science · 2014Article
- Oral antigens induce rheumatoid arthritis-like inflammation in a rat model.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2013Article
- IL-9(+) IL-10(+) T cells link immediate allergic response to late phase reaction.Clinical and experimental immunology · 2011Article
- Concurrent exposure to microbial products and food antigens triggers initiation of food allergy.North American journal of medical sciences · 2009Article
- Pathophysiology of food-induced anaphylaxis.Current allergy and asthma reports · 2008Review
- Allergen-IgE complexes trigger CD23-dependent CCL20 release from human intestinal epithelial cells.Gastroenterology · 2007Article
- Chronic psychological stress in rats induces intestinal sensitization to luminal antigens.The American journal of pathology · 2006Article
- Eosinophilia in the upper gastrointestinal tract is not a characteristic feature in cow's milk sensitive gastro-oesophageal reflux disease. Measurement by two methodologies.Journal of clinical pathology · 2006Article
- A murine model of ulcerative colitis: induced with sinusitis-derived superantigen and food allergen.BMC gastroenterology · 2005Article
- Protease-activated receptors: regulation of neuronal function.Neuromolecular medicine · 2005Review
- The pathobiology of eosinophilic gastroenteritis of childhood: is it really the eosinophil, allergic mediated, or something else?Current gastroenterology reports · 2004Review
- Small bowel review: Normal physiology, part 1.Digestive diseases and sciences · 2003Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Relatively little information exists concerning the late phase of the allergic reaction in the gastrointestinal tract. Here, we characterized jejunal mucosal pathophysiology and inflammation after oral antigen challenge of sensitized rats, and examined the role of mast cells in events after challenge. Sprague-Dawley rats, mast cell-deficient (Ws/Ws), and +/+ control rats were sensitized to horseradish peroxidase, and challenged intragastrically with antigen 14 days later. Jejunal segments were obtained at 0.5 to 72 hours after challenge for functional assessment in Ussing chambers and for morphological assessment by light and electron microscopy. Intestine from sensitized Sprague-Dawley rats demonstrated enhanced ion secretion and permeability at all times after challenge. Electron microscopy revealed abnormal mitochondria within enterocytes and disruption of the epithelial basement membrane associated with influx into the mucosa of mast cells, eosinophils, neutrophils, and mononuclear cells. Many inflammatory cells appeared activated. In contrast, antigen-challenged Ws/Ws rats demonstrated no functional changes or inflammatory cell infiltrate. We conclude that oral antigen challenge of sensitized rats induces sustained epithelial dysfunction. Mast cells mediate both epithelial pathophysiology and recruitment of additional inflammatory cells that may contribute to persistent pathophysiology and symptoms.
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