ArticleThe American journal of pathology2001
Liver repopulation and correction of metabolic liver disease by transplanted adult mouse pancreatic cells.
Article in The American journal of pathology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Liver fibrosis pathologies and potentials of RNA based therapeutics modalities.Drug delivery and translational research · 2024Review
- mRNA-based therapy proves superior to the standard of care for treating hereditary tyrosinemia 1 in a mouse model.Molecular therapy. Methods & clinical development · 2022Article
- Efficient liver repopulation of transplanted hepatocyte prevents cirrhosis in a rat model of hereditary tyrosinemia type I.Scientific reports · 2016Article
- The organoid-initiating cells in mouse pancreas and liver are phenotypically and functionally similar.Stem cell research · 2014Article
- Murine embryonic stem cell-derived hepatocytes correct metabolic liver disease after serial liver repopulation.The international journal of biochemistry & cell biology · 2012Article
- A rare case of metastatic pancreatic hepatoid carcinoma treated with sorafenib.Journal of gastrointestinal cancer · 2012Article
- Rodent animal models for surrogate analysis of cell therapy in acute liver failure.Frontiers in physiology · 2012Article
- Article
- Model systems and experimental conditions that lead to effective repopulation of the liver by transplanted cells.The international journal of biochemistry & cell biology · 2011Review
- Dexamethasone treatment induces the reprogramming of pancreatic acinar cells to hepatocytes and ductal cells.PloS one · 2010Article
- Stem cells and liver regeneration.Gastroenterology · 2009Review
- Reversal of diabetes in mice by intrahepatic injection of bone-derived GFP-murine mesenchymal stem cells infected with the recombinant retrovirus-carrying human insulin gene.World journal of surgery · 2007Article
- Stimulation of cAMP signalling allows isolation of clonal pancreatic precursor cells from adult mouse pancreas.Diabetologia · 2006Article
- Hepatocyte-like cells transdifferentiated from a pancreatic origin can support replication of hepatitis B virus.Journal of virology · 2005Article
- Hepatocyte progenitors in man and in rodents--multiple pathways, multiple candidates.International journal of experimental pathology · 2005Review
- Hepatic differentiation capability of rat bone marrow-derived mesenchymal stem cells and hematopoietic stem cells.World journal of gastroenterology · 2004Article
- Human pancreatic islet-derived progenitor cell engraftment in immunocompetent mice.The American journal of pathology · 2004Article
- Hepatic stem cells: from inside and outside the liver?Cell proliferation · 2004Review
- The new stem cell biology: something for everyone.Molecular pathology : MP · 2003Review
- Multipotent adult progenitor cells from bone marrow differentiate into functional hepatocyte-like cells.The Journal of clinical investigation · 2002Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
The emergence of cells with hepatocellular properties in the adult pancreas has been described in several experimental models. To determine whether adult pancreas contains cells that can give rise to therapeutically useful and biochemically normal hepatocytes, we transplanted suspensions of wild-type mouse pancreatic cells into syngeneic recipients deficient in fumarylacetoacetate hydrolase and manifesting tyrosinemia. Four of 34 (12%) mutant mice analyzed were fully rescued by donor-derived cells and had normal liver function. Ten additional mice (29%) showed histological evidence of donor-derived hepatocytes in the liver. Previous work has suggested that pancreatic liver precursors reside within or close to pancreatic ducts. We therefore performed additional transplantations using either primary cell suspensions enriched for ducts or cultured ducts. Forty-four mutant mice were transplanted with cells enriched for pancreatic duct cells, but only three of the 34 (9%) recipients analyzed displayed donor-derived hepatocytes. In addition, 28 of the fumarylacetoacetate hydrolase-deficient mice were transplanted with cultured pancreatic duct cells, but no donor-derived hepatocytes were observed. Our results demonstrate for the first time that adult mouse pancreas contains hepatocyte progenitor cells capable of significant therapeutic liver reconstitution. However, contrary to previous reports, we were unable to detect these cells within the duct compartment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.