ArticleProceedings of the National Academy of Sciences of the United States of America2001
Nodes of Ranvier form in association with ezrin-radixin-moesin (ERM)-positive Schwann cell processes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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Who cites it
55 citing papers in PubMed, 125 citations in OpenAlex.
- Development of a 3-dimensional organotypic model with characteristics of peripheral sensory nerves.Cell reports methods · 2024Article
- FERM domain-containing proteins are active components of the cell nucleus.Life science alliance · 2024Review
- A bipartite NLS motif mediates the nuclear import ofFrontiers in cell and developmental biology · 2024Article
- Cellular mechanisms of heterogeneity in NF2-mutant schwannoma.Nature communications · 2023Article
- Identification of Myelin Basic Protein Proximity Interactome Using TurboID Labeling Proteomics.Cells · 2023Article
- Comprehensive Atlas of the Myelin Basic Protein Interaction Landscape.Biomolecules · 2021Article
- Mechanisms of node of Ranvier assembly.Nature reviews. Neuroscience · 2021Review
- Accumulation of Neurofascin at Nodes of Ranvier Is Regulated by a Paranodal Switch.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Review
- NF2 Inhibits Proliferation and Cancer Stemness in Breast Cancer.Open medicine (Warsaw, Poland) · 2020Article
- Perspectives for Ezrin and Radixin in Astrocytes: Kinases, Functions and Pathology.International journal of molecular sciences · 2019Review
- Article
- Olfactory receptor neuronal dendrites become mostly intra-sustentacularly enwrapped upon maturity.Journal of anatomy · 2018Article
- Fetal extracellular matrix nerve wraps locally improve peripheral nerve remodeling after complete transection and direct repair in rat.Scientific reports · 2018Article
- Ultrastructural anatomy of nodes of Ranvier in the peripheral nervous system as revealed by STED microscopy.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Autoimmune antigenic targets at the node of Ranvier in demyelinating disorders.Nature reviews. Neurology · 2015Review
- Amyloid precursor protein at node of Ranvier modulates nodal formation.Cell adhesion & migration · 2014Article
- The making of a node: a co-production of neurons and glia.Current opinion in neurobiology · 2013Review
- Neuro-glial interactions at the nodes of Ranvier: implication in health and diseases.Frontiers in cellular neuroscience · 2013Review
- Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
In the adult peripheral nerve, microvillous processes of myelinating Schwann cells project to the nodes of Ranvier; their composition and physiologic function have not been established. As the ezrin-radixin-moesin (ERM) proteins are expressed in the microvilli of many epithelial cells, we have examined the expression and distribution of these proteins in Schwann cells and neurons in vitro and in vivo. Cultured Schwann cells express high levels of all three proteins and the ezrin-binding protein 50, whereas neurons express much lower, although detectable, levels of radixin and moesin. Ezrin is specific for Schwann cells. All three ERM proteins are expressed predominantly at the membrane of cultured Schwann cells, notably in their microvilli. In vivo, the ERM proteins are concentrated strikingly in the nodal processes of myelinating Schwann cells. Because these processes are devoid of myelin proteins, they represent a unique compartment of the myelinating Schwann cell. During development, the ERM proteins become concentrated at the ends of Schwann cells before myelin basic protein expression, demonstrating that Schwann cells are polarized longitudinally at the onset of myelination. ERM-positive Schwann cell processes overlie and are associated closely with nascent nodes of Ranvier, identified by clusters of ankyrin G. Ankyrin accumulation at the node precedes that of Caspr at the paranodes and therefore does not depend on the presence of mature paranodal junctions. These results demonstrate that nodes of Ranvier in the peripheral nervous system form in contact with specialized processes of myelinating Schwann cells that are highly enriched in ERM proteins.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.