ArticleMolecular and cellular biology2001
Binding of TATA binding protein to a naturally positioned nucleosome is facilitated by histone acetylation.
Article in Molecular and cellular biology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 61 citations in OpenAlex.
- A novel histone deacetylase inhibitor LT-548-133-1 induces apoptosis by inhibiting HDAC and interfering with microtubule assembly in MCF-7 cells.Investigational new drugs · 2021Article
- CpG content-dependent associations between transcription factors and histone modifications.PloS one · 2021Article
- Histone Methylation in Nickel-Smelting Industrial Workers.PloS one · 2015Article
- The conformational state of the nucleosome entry-exit site modulates TATA box-specific TBP binding.Nucleic acids research · 2014Article
- The faah gene is the first direct target of estrogen in the testis: role of histone demethylase LSD1.Cellular and molecular life sciences : CMLS · 2012Article
- Sodium butyrate stimulates expression of fibroblast growth factor 21 in liver by inhibition of histone deacetylase 3.Diabetes · 2012Article
- Chromatin context dominates estrogen regulation of pS2 gene expression.Experimental cell research · 2008Article
- HMGN1 modulates estrogen-mediated transcriptional activation through interactions with specific DNA-binding transcription factors.Molecular and cellular biology · 2007Article
- An unmethylated 3' promoter-proximal region is required for efficient transcription initiation.PLoS genetics · 2007Article
- A role for gcn5-mediated global histone acetylation in transcriptional regulation.Molecular and cellular biology · 2006Article
- Dimethylation of histone H3 at lysine 36 demarcates regulatory and nonregulatory chromatin genome-wide.Molecular and cellular biology · 2005Article
- The yeast FACT complex has a role in transcriptional initiation.Molecular and cellular biology · 2005Article
- Role for Nhp6, Gcn5, and the Swi/Snf complex in stimulating formation of the TATA-binding protein-TFIIA-DNA complex.Molecular and cellular biology · 2004Article
- The acetyltransferase 60 kDa trans-acting regulatory protein of HIV type 1-interacting protein (Tip60) interacts with the translocation E26 transforming-specific leukaemia gene (TEL) and functions as a transcriptional co-repressor.The Biochemical journal · 2003Article
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- Yeast Ume6p repressor permits activator binding but restricts TBP binding at the HOP1 promoter.Nucleic acids research · 2003Article
- Regulation of TATA-binding protein binding by the SAGA complex and the Nhp6 high-mobility group protein.Molecular and cellular biology · 2003Article
- Transcriptional inhibition of genes with severe histone h3 hypoacetylation in the coding region.Molecular cell · 2002Article
- Targeted recruitment of Rpd3 histone deacetylase represses transcription by inhibiting recruitment of Swi/Snf, SAGA, and TATA binding protein.Molecular and cellular biology · 2002Article
- Targeted histone acetylation at the yeast CUP1 promoter requires the transcriptional activator, the TATA boxes, and the putative histone acetylase encoded by SPT10.Molecular and cellular biology · 2002Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The TATA sequence of the human, estrogen-responsive pS2 promoter is complexed in vivo with a rotationally and translationally positioned nucleosome (NUC T). Using a chromatin immunoprecipitation assay, we demonstrate that TATA binding protein (TBP) does not detectably interact with this genomic binding site in MCF-7 cells in the absence of transcriptional stimuli. Estrogen stimulation of these cells results in hyperacetylation of both histones H3 and H4 within the pS2 chromatin encompassing NUC T and the TATA sequence. Concurrently, TBP becomes associated with the pS2 promoter region. The relationship between histone hyperacetylation and the binding of TBP was assayed in vitro using an in vivo-assembled nucleosomal array over the pS2 promoter. With chromatin in its basal state, the binding of TBP to the pS2 TATA sequence at the edge of NUC T was severely restricted, consistent with our in vivo data. Acetylation of the core histones facilitated the binding of TBP to this nucleosomal TATA sequence. Therefore, we demonstrate that one specific, functional consequence of induced histone acetylation at a native promoter is the alleviation of nucleosome-mediated repression of the binding of TBP. Our data support a fundamental role for histone acetylation at genomic promoters in transcriptional activation by nuclear receptors and provide a general mechanism for rapid and reversible transcriptional activation from a chromatin template.
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