ArticleMolecular and cellular biology2001
Candida albicans INT1-induced filamentation in Saccharomyces cerevisiae depends on Sla2p.
Article in Molecular and cellular biology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 46 citations in OpenAlex.
- Endocytosis Mediated byMicroorganisms · 2026Article
- Influence of Ubiquitin Mutations over Molecular Markers Contributing to Pathogenesis of Candida albicans.Cell biochemistry and biophysics · 2025Article
- Comprehensive Interactome Analysis for the Sole Adenylyl Cyclase Cyr1 of Candida albicans.Microbiology spectrum · 2022Article
- From Jekyll to Hyde: The Yeast-Hyphal Transition ofPathogens (Basel, Switzerland) · 2021Review
- The regulation of hyphae growth inVirulence · 2020Review
- The Role of Secretory Pathways inJournal of fungi (Basel, Switzerland) · 2020Review
- The anillin-related Int1 protein and the Sep7 septin collaborate to maintain cellular ploidy in Candida albicans.Scientific reports · 2018Article
- The spatial distribution of the exocyst and actin cortical patches is sufficient to organize hyphal tip growth.Eukaryotic cell · 2013Article
- Motor protein Myo5p is required to maintain the regulatory circuit controlling WOR1 expression in Candida albicans.Eukaryotic cell · 2012Article
- Growth of Candida albicans hyphae.Nature reviews. Microbiology · 2011Review
- Endocytic machinery protein SlaB is dispensable for polarity establishment but necessary for polarity maintenance in hyphal tip cells of Aspergillus nidulans.Eukaryotic cell · 2010Article
- The RIM101 signal transduction pathway regulates Candida albicans virulence during experimental keratomycosis.Investigative ophthalmology & visual science · 2010Article
- Forward genetics in Candida albicans that reveals the Arp2/3 complex is required for hyphal formation, but not endocytosis.Molecular microbiology · 2010Article
- SLA2 mutations cause SWE1-mediated cell cycle phenotypes in Candida albicans and Saccharomyces cerevisiae.Microbiology (Reading, England) · 2009Article
- Endocytosis is crucial for cell polarity and apical membrane recycling in the filamentous fungus Aspergillus oryzae.Eukaryotic cell · 2009Article
- Environmental sensing and signal transduction pathways regulating morphopathogenic determinants of Candida albicans.Microbiology and molecular biology reviews : MMBR · 2007Review
- The MAD1 adhesin of Metarhizium anisopliae links adhesion with blastospore production and virulence to insects, and the MAD2 adhesin enables attachment to plants.Eukaryotic cell · 2007Article
- Morphogenesis in Candida albicans.Annual review of microbiology · 2007Review
- Transcript profiles of Candida albicans cortical actin patch mutants reflect their cellular defects: contribution of the Hog1p and Mkc1p signaling pathways.Eukaryotic cell · 2006Article
- Small-molecule inhibitors of the budded-to-hyphal-form transition in the pathogenic yeast Candida albicans.Antimicrobial agents and chemotherapy · 2005Article
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
Abstract
The Candida albicans INT1 gene is important for hyphal morphogenesis, adherence, and virulence (C. Gale, C. Bendel, M. McClellan, M. Hauser, J. M. Becker, J. Berman, and M. Hostetter, Science 279:1355-1358, 1998). The ability to switch between yeast and hyphal morphologies is an important virulence factor in this fungal pathogen. When INT1 is expressed in Saccharomyces cerevisiae, cells grow with a filamentous morphology that we exploited to gain insights into how C. albicans regulates hyphal growth. In S. cerevisiae, INT1-induced filamentous growth was affected by a small subset of actin mutations and a limited set of actin-interacting proteins including Sla2p, an S. cerevisiae protein with similarity in its C terminus to mouse talin. Interestingly, while SLA2 was required for INT1-induced filamentous growth, it was not required for polarized growth in response to several other conditions, suggesting that Sla2p is not required for polarized growth per se. The morphogenesis checkpoint, mediated by Swe1p, contributes to INT1-induced filamentous growth; however, epistasis analysis suggests that Sla2p and Swe1p contribute to INT1-induced filamentous growth through independent pathways. The C. albicans SLA2 homolog (CaSLA2) complements S. cerevisiae sla2Delta mutants for growth at 37 degrees C and INT1-induced filamentous growth. Furthermore, in a C. albicans Casla2/Casla2 strain, hyphal growth did not occur in response to either nutrient deprivation or to potent stimuli, such as mammalian serum. Thus, through analysis of INT1-induced filamentous growth in S. cerevisiae, we have identified a C. albicans gene, SLA2, that is required for hyphal growth in C. albicans.
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