ArticleMolecular and cellular biology2001
Identification of a major cyclic AMP-dependent protein kinase A phosphorylation site within the cytoplasmic tail of the low-density lipoprotein receptor-related protein: implication for receptor-mediated endocytosis.
Article in Molecular and cellular biology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 74 citations in OpenAlex.
- Expression profiles of metallothionein-I/II and megalin/LRP-2 in uterine cervical squamous lesions.Virchows Archiv : an international journal of pathology · 2021Article
- Canonical Wnt signaling in diabetic retinopathy.Vision research · 2017Review
- LRP1-Dependent BMPER Signaling Regulates Lipopolysaccharide-Induced Vascular Inflammation.Arteriosclerosis, thrombosis, and vascular biology · 2017Article
- Endocytic receptor LRP2/megalin-of holoprosencephaly and renal Fanconi syndrome.Pflugers Archiv : European journal of physiology · 2017Review
- The P2Y2 receptor mediates uptake of matrix-retained and aggregated low density lipoprotein in primary vascular smooth muscle cells.Atherosclerosis · 2016Article
- Low Density Lipoprotein Receptor Related Proteins as Regulators of Neural Stem and Progenitor Cell Function.Stem cells international · 2016Review
- Role of cAMP-phosphodiesterase 1C signaling in regulating growth factor receptor stability, vascular smooth muscle cell growth, migration, and neointimal hyperplasia.Circulation research · 2015Article
- Impaired vascular-mediated clearance of brain amyloid beta in Alzheimer's disease: the role, regulation and restoration of LRP1.Frontiers in aging neuroscience · 2015Review
- Article
- LRP1-dependent endocytic mechanism governs the signaling output of the bmp system in endothelial cells and in angiogenesis.Circulation research · 2012Article
- Urokinase-type plasminogen activator (uPA) induces pulmonary microvascular endothelial permeability through low density lipoprotein receptor-related protein (LRP)-dependent activation of endothelial nitric-oxide synthase.The Journal of biological chemistry · 2011Article
- Inactivation of the proximal NPXY motif impairs early steps in LRP1 biosynthesis.Cellular and molecular life sciences : CMLS · 2010Article
- Norrin attenuates protease-mediated death of transformed retinal ganglion cells.Molecular vision · 2009Article
- Polarized traffic of LRP1 involves AP1B and SNX17 operating on Y-dependent sorting motifs in different pathways.Molecular biology of the cell · 2009Article
- Protein kinase C-alpha-mediated regulation of low-density lipoprotein receptor related protein and urokinase increases astrocytoma invasion.Cancer research · 2007Article
- pkaPS: prediction of protein kinase A phosphorylation sites with the simplified kinase-substrate binding model.Biology direct · 2007Article
- Mutant Lrp1 knock-in mice generated by recombinase-mediated cassette exchange reveal differential importance of the NPXY motifs in the intracellular domain of LRP1 for normal fetal development.Molecular and cellular biology · 2006Article
- Sorting nexin 17 facilitates LRP recycling in the early endosome.The EMBO journal · 2005Article
- Apolipoprotein E-induced cell signaling in the vessel wall.Reviews in endocrine & metabolic disorders · 2004Review
- Neuronal LRP1 functionally associates with postsynaptic proteins and is required for normal motor function in mice.Molecular and cellular biology · 2004Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
Abstract
The low-density lipoprotein (LDL) receptor-related protein (LRP) is a multiligand endocytic receptor that belongs to the LDL receptor family. Recently, studies have revealed new roles of LDL receptor family members as transducers of extracellular signals. Our previous studies have demonstrated LRP phosphorylation within its cytoplasmic tail, but the nature of LRP phosphorylation and its potential function was unknown. In the present study using both in vivo and in vitro analysis, we found that LRP phosphorylation is mediated by the cAMP-dependent protein kinase A (PKA). Using site-directed mutagenesis and LRP minireceptor constructs, we further identified the predominant LRP phosphorylation site at serine 76 of its cytoplasmic tail. Finally, we demonstrated that mutations of serine 76, which abolish LRP phosphorylation by PKA, result in a decrease in the initial endocytosis rate of LRP and a lower efficiency in delivery of ligand for degradation. Thus, the role of PKA phosphorylation of LRP in receptor-mediated endocytosis may provide a mechanism by which the endocytic function of LRP can be regulated by external signals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.