ArticleMolecular and cellular biology2001
Region of yeast TAF 130 required for TFIID to associate with promoters.
Article in Molecular and cellular biology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 21 citations in OpenAlex.
- Zinc knuckle of TAF1 is a DNA binding module critical for TFIID promoter occupancy.Scientific reports · 2018Article
- TAF4 nucleates a core subcomplex of TFIID and mediates activated transcription from a TATA-less promoter.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- TAF1 histone acetyltransferase activity in Sp1 activation of the cyclin D1 promoter.Molecular and cellular biology · 2005Article
- Molecular and genetic characterization of a Taf1p domain essential for yeast TFIID assembly.Molecular and cellular biology · 2004Article
- Mapping key functional sites within yeast TFIID.The EMBO journal · 2004Article
- Protein-protein interaction map for yeast TFIID.Nucleic acids research · 2003Article
- The Ccr4-not complex and yTAF1 (yTaf(II)130p/yTaf(II)145p) show physical and functional interactions.Molecular and cellular biology · 2002Article
- Evidence that TAF-TATA box-binding protein interactions are required for activated transcription in mammalian cells.Molecular and cellular biology · 2002Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
TFIID, a multiprotein complex comprising the TATA-binding protein (TBP) and TBP-associated factors (TAFs), associates specifically with core promoters and nucleates the assembly the RNA polymerase II transcription machinery. In yeast cells, TFIID is not generally required for transcription, although it plays an important role at many promoters. Understanding of the specific functions and physiological roles of individual TAFs within TFIID has been hampered by the fact that depletion or thermal inactivation of individual TAFs generally results in dissociation of the TFIID complex. We describe here C-terminally deleted derivatives of yeast TAF130 that assemble into normal TFIID complexes but are transcriptionally inactive in vivo. In vivo, these mutant TFIID complexes are dramatically reduced in their ability to associate with all promoters tested. In vitro, a TFIID complex containing a deleted form of TAF130 associates poorly with DNA, but it is unaffected for interacting with transcriptional activation domains. These results suggest that the C-terminal region of TAF130 is required for TFIID to associate with promoters.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.