ArticleMolecular and cellular biology2001
Serum response factor-GATA ternary complex required for nuclear signaling by a G-protein-coupled receptor.
Article in Molecular and cellular biology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 117 citations in OpenAlex.
- Review of the Protective Mechanism of Curcumin on Cardiovascular Disease.Drug design, development and therapy · 2024Review
- Differential regulation of cranial and cardiac neural crest by serum response factor and its cofactors.eLife · 2022Article
- Article
- Novel mutations of the SRF gene in Chinese sporadic conotruncal heart defect patients.BMC medical genetics · 2020Article
- Mechanosensitive transcriptional coactivators MRTF-A and YAP/TAZ regulate nucleus pulposus cell phenotype through cell shape.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- miR-486 is modulated by stretch and increases ventricular growth.JCI insight · 2019Article
- Article
- The multifaceted role of natriuretic peptides in metabolic syndrome.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2017Review
- The Early-Onset Myocardial Infarction Associated PHACTR1 Gene Regulates Skeletal and Cardiac Alpha-Actin Gene Expression.PloS one · 2015Article
- Overexpression of p49/STRAP alters cellular cytoskeletal structure and gross anatomy in mice.BMC cell biology · 2014Article
- Heart failure in congenital heart disease: the role of genes and hemodynamics.Pflugers Archiv : European journal of physiology · 2014Review
- Glucose-induced cell signaling in the pathogenesis of diabetic cardiomyopathy.Heart failure reviews · 2014Review
- Megakaryocytic leukemia 1 (MKL1) ties the epigenetic machinery to hypoxia-induced transactivation of endothelin-1.Nucleic acids research · 2013Article
- Dissociation of cardiogenic and postnatal myocardial activities of GATA4.Molecular and cellular biology · 2012Article
- Transcription factors in heart: promising therapeutic targets in cardiac hypertrophy.Current cardiology reviews · 2011Review
- Mitogen-activated protein kinase-activated protein kinase 2 in angiotensin II-induced inflammation and hypertension: regulation of oxidative stress.Hypertension (Dallas, Tex. : 1979) · 2011Article
- ZFP260 is an inducer of cardiac hypertrophy and a nuclear mediator of endothelin-1 signaling.The Journal of biological chemistry · 2011Article
- Modulation of adverse cardiac remodeling by STARS, a mediator of MEF2 signaling and SRF activity.The Journal of clinical investigation · 2007Article
- The Kruppel-like transcription factor KLF13 is a novel regulator of heart development.The EMBO journal · 2006Article
- In Vivo beta-adrenergic activation of atrial natriuretic factor (ANF) reporter expression.Molecular and cellular biochemistry · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Endothelins are a family of biologically active peptides that are critical for development and function of neural crest-derived and cardiovascular cells. These effects are mediated by two G-protein-coupled receptors and involve transcriptional regulation of growth-responsive and/or tissue-specific genes. We have used the cardiac ANF promoter, which represents the best-studied tissue-specific endothelin target, to elucidate the nuclear pathways responsible for the transcriptional effects of endothelins. We found that cardiac-specific response to endothelin 1 (ET-1) requires the combined action of the serum response factor (SRF) and the tissue-restricted GATA proteins which bind over their adjacent sites, within a 30-bp ET-1 response element. We show that SRF and GATA proteins form a novel ternary complex reminiscent of the well-characterized SRF-ternary complex factor interaction required for transcriptional induction of c-fos in response to growth factors. In transient cotransfections, GATA factors and SRF synergistically activate atrial natriuretic factor and other ET-1-inducible promoters that contain both GATA and SRF binding sites. Thus, GATA factors may represent a new class of tissue-specific SRF accessory factors that account for muscle- and other cell-specific SRF actions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.