ArticleThe Journal of physiology2001
Comparison of spontaneous and noradrenaline-evoked non-selective cation channels in rabbit portal vein myocytes.
Article in The Journal of physiology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 27 citations in OpenAlex.
- Molecular expression and functional role of canonical transient receptor potential channels in airway smooth muscle cells.Advances in experimental medicine and biology · 2011Review
- Functional role of canonical transient receptor potential 1 and canonical transient receptor potential 3 in normal and asthmatic airway smooth muscle cells.American journal of respiratory cell and molecular biology · 2010Article
- Diverse properties of store-operated TRPC channels activated by protein kinase C in vascular myocytes.The Journal of physiology · 2008Article
- Angiotensin II activates two cation conductances with distinct TRPC1 and TRPC6 channel properties in rabbit mesenteric artery myocytes.The Journal of physiology · 2006Article
- Dual effect of calmodulin on store-operated Ca2+ -permeable cation channels in rabbit portal vein myocytes.British journal of pharmacology · 2006Article
- Signal transduction pathways and gating mechanisms of native TRP-like cation channels in vascular myocytes.The Journal of physiology · 2006Review
- Facilitatory effect of Ins(1,4,5)P3 on store-operated Ca2+-permeable cation channels in rabbit portal vein myocytes.The Journal of physiology · 2005Article
- Extracellular Mg(2+) blocks endothelin-1-induced contraction through the inhibition of non-selective cation channels in coronary smooth muscle.Pflugers Archiv : European journal of physiology · 2004Article
- Inhibitory regulation of constitutive transient receptor potential-like cation channels in rabbit ear artery myocytes.The Journal of physiology · 2004Article
- Phospholipase C, but not InsP3 or DAG, -dependent activation of the muscarinic receptor-operated cation current in guinea-pig ileal smooth muscle cells.British journal of pharmacology · 2004Article
- Synergism between inositol phosphates and diacylglycerol on native TRPC6-like channels in rabbit portal vein myocytes.The Journal of physiology · 2003Article
- Properties of a constitutively active Ca2+-permeable non-selective cation channel in rabbit ear artery myocytes.The Journal of physiology · 2003Article
- Activation of store-operated channels by noradrenaline via protein kinase C in rabbit portal vein myocytes.The Journal of physiology · 2002Article
- The effect of external divalent cations on spontaneous non-selective cation channel currents in rabbit portal vein myocytes.The Journal of physiology · 2001Article
- Comparison of spontaneous and noradrenaline-evoked non-selective cation channels in rabbit portal vein myocytes.The Journal of physiology · 2001Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The properties of non-selective cation channels were studied in rabbit portal vein smooth muscle cells in K+-free conditions with patch pipette techniques. In about 45 % of isolated outside-out patches spontaneous channel currents with a unitary conductance of 23 pS were observed. The reversal potential was +11 mV which was shifted to more negative values and the unitary conductance was reduced when part of the external Na+ was replaced by Tris. At negative potentials the probability of opening (Po) was low and the open time distributions were described by two exponentials with time constants of about 1 and 7 ms. At positive potentials Po and the longer mean open time were greatly increased. The channel exhibited bursting behaviour and the burst duration distributions were described by two exponentials with time constants of about 3 and 15 ms. At positive potentials the longer burst duration was increased substantially. Application of noradrenaline and the diacylglycerol analogue 1-oleoyl-2-acetyl-sn-glycerol (OAG) to the external membrane of quiescent patches evoked single-channel activity with a unitary conductance of about 23 pS and with similar kinetic behaviour to that of the spontaneous channel currents. In conclusion, noradrenaline and OAG activate non-selective cation channel currents in excised patches of rabbit portal vein myocytes with a unitary conductance and kinetic properties that are similar to those of spontaneous channel currents. These channels have two open states and exhibit bursting behaviour. It is suggested that these channels underlie the whole-cell currents evoked by noradrenaline and OAG.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.