ArticleJournal of clinical microbiology2001
Diagnosing genital ulcer disease in a clinic for sexually transmitted diseases in Amsterdam, The Netherlands.
Article in Journal of clinical microbiology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 114 citations in OpenAlex.
- Infections caused byClinical microbiology reviews · 2024Review
- Timely Diagnosis of Incubating Syphilis Infections Using Treponema pallidum Transcription-Mediated Amplification Assay.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023Article
- Prevalence and risk factors associated with Haemophilus ducreyi cutaneous ulcers in Cameroon.PLoS neglected tropical diseases · 2023Article
- Use of a Multiplex PCR Assay To Assess the Presence of Treponema pallidum in Mucocutaneous Ulcerations in Patients with Suspected Syphilis.Journal of clinical microbiology · 2021Article
- Article
- Haemophilus ducreyi cutaneous ulcer contracted at Seram Island, Indonesia, presented in the Netherlands.PLoS neglected tropical diseases · 2018Article
- Etiology of genital ulcer disease in a sexually transmitted infection reference center in Manaus, Brazilian Amazon.PloS one · 2013Article
- Genital Ulcer Disease: How Worrisome Is It Today? A Status Report from New Delhi, India.Journal of sexually transmitted diseases · 2013Article
- Risk factors, healthcare-seeking and sexual behaviour among patients with genital ulcers in Zambia.BMC public health · 2012Article
- Herpes simplex virus type 1 is the leading cause of genital herpes in New Brunswick.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2012Article
- Clinical value of Treponema pallidum real-time PCR for diagnosis of syphilis.Journal of clinical microbiology · 2010Article
- TprK gene regions are not suitable for epidemiological syphilis typing.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2009Article
- Molecular characterization of syphilis in patients in Canada: azithromycin resistance and detection of Treponema pallidum DNA in whole-blood samples versus ulcerative swabs.Journal of clinical microbiology · 2009Article
- Development of a real-time PCR assay to detect Treponema pallidum in clinical specimens and assessment of the assay's performance by comparison with serological testing.Journal of clinical microbiology · 2007Article
- The CD14 functional gene polymorphism -260 C>T is not involved in either the susceptibility to Chlamydia trachomatis infection or the development of tubal pathology.BMC infectious diseases · 2005Article
- Interrelationship between polymorphisms of incA, fusogenic properties of Chlamydia trachomatis strains, and clinical manifestations in patients in The Netherlands.Journal of clinical microbiology · 2005Article
- The laboratory diagnosis of Haemophilus ducreyi.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2005Article
- Increasing relative prevalence of HSV-2 infection among men with genital ulcers from a mining community in South Africa.Sexually transmitted infections · 2003Article
- Diagnosing herpesvirus infections by real-time amplification and rapid culture.Journal of clinical microbiology · 2003Article
- Use of a fragment of glycoprotein G-2 produced in the baculovirus expression system for detecting herpes simplex virus type 2-specific antibodies.Journal of clinical microbiology · 2002Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The most common etiologic agents of genital ulcer disease (GUD) are herpes simplex virus type 1 (HSV-1), HSV-2, Treponema pallidum, and Haemophilus ducreyi. In an outpatient clinic for sexually transmitted diseases in Amsterdam, The Netherlands, specimens from 372 patients with GUD were collected from February to November 1996. Sera were collected at the time of the symptoms and, for most patients, also during follow-up visits. Swabs in viral transport medium were used for HSV culture and for detection of DNA. The most prevalent pathogen found was HSV-2, which was detected by culture in 35% of the patients and by PCR in 48% of the patients. Also, HSV-1 infection was more often detected by PCR (7.8%) than by culture (5.6%). Evidence for an active infection with T. pallidum was found in 1.9% of the patients, using serological tests. A multiplex PCR for simultaneous T. pallidum and H. ducreyi DNA detection was positive for T. pallidum in 3.3% of the samples and for H. ducreyi in only 0.9% (3 out of 368) of the samples. The sensitivity of the PCR was superior to that of culture for HSV detection and to that of serology for T. pallidum detection. Specific H. ducreyi immunoglobulin G antibodies were detected in sera of 5.2% of the patients, with no concordance between serology and PCR. In 37% of the cases, none of the tested microorganisms was detected. Performance of PCR in addition to conventional techniques significantly improved the diagnosis of GUD.
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