ArticleJournal of bacteriology2001
Drosophila as a model host for Pseudomonas aeruginosa infection.
Article in Journal of bacteriology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
90 citing papers in PubMed, 226 citations in OpenAlex.
- Drosophila melanogaster as a model host for studying Pseudomonas aeruginosa feeding infection.Nature protocols · 2026Review
- When Small Meets Smaller: Immune Modulation and Virulence Strategies in Insect-Bacteria Interactions.Insects · 2026Review
- Antibacterial Efficacy ofPathogens (Basel, Switzerland) · 2026Article
- N-acetyl-glucosamine primes Pseudomonas aeruginosa for virulence through a type IV pili/cAMP-mediated morphology transition.Nature communications · 2025Article
- Investigating the immunomodulatory effects of honeybee venom peptide apamin inInfection and immunity · 2025Article
- Bacteria in Fluid Flow.Journal of bacteriology · 2023Review
- The transcriptomic signature of responses to larval crowding in Drosophila melanogaster.Insect science · 2023Article
- Flagella, Chemotaxis and Surface Sensing.Advances in experimental medicine and biology · 2022Article
- Pseudomonas aeruginosa Quorum Sensing.Advances in experimental medicine and biology · 2022Article
- An Overview of Biological and Computational Methods for Designing Mechanism-Informed Anti-biofilm Agents.Frontiers in microbiology · 2021Review
- The hypothetical periplasmic protein PA1624 from Pseudomonas aeruginosa folds into a unique two-domain structure.Acta crystallographica. Section F, Structural biology communications · 2020Article
- Animal infection models using non-mammals.Microbiology and immunology · 2020Review
- iTRAQ-Based Comparative Proteomic Analysis of Larval Midgut From the Beet Armyworm,Frontiers in physiology · 2020Article
- Review
- Context-Specific Requirement of Forty-Four Two-Component Loci in Pseudomonas aeruginosa Swarming.iScience · 2019Article
- Review
- Phage Morons Play an Important Role in Pseudomonas aeruginosa Phenotypes.Journal of bacteriology · 2018Article
- Drosophila melanogaster as a polymicrobial infection model for Pseudomonas aeruginosa and Staphylococcus aureus.Journal of microbiology (Seoul, Korea) · 2018Article
- Role of Fly Cleaning Behavior on Carriage of Escherichia coli and Pseudomonas aeruginosa.Journal of medical entomology · 2017Article
- Impact of Azithromycin on the Quorum Sensing-Controlled Proteome of Pseudomonas aeruginosa.PloS one · 2016Article
30 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Using the fruit fly Drosophila melanogaster as model host, we have identified mutants of the bacterium Pseudomonas aeruginosa with reduced virulence. Strikingly, all strains strongly impaired in fly killing also lacked twitching motility; most such strains had a mutation in pilGHIJKL chpABCDE, a gene cluster known to be required for twitching motility and potentially encoding a signal transduction system. The pil chp genes appear to control the expression of additional virulence factors, however, since the wild-type fly-killing phenotype of a subset of mutants isolated on the basis of their compact colony morphology indicated that twitching motility itself was not required for full virulence in the fly.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.