ArticleJournal of bacteriology2001
Myxococcus xanthus mokA encodes a histidine kinase-response regulator hybrid sensor required for development and osmotic tolerance.
Article in Journal of bacteriology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 19 citations in OpenAlex.
- Phosphate flow between hybrid histidine kinases CheA₃ and CheS₃ controls Rhodospirillum centenum cyst formation.PLoS genetics · 2013Article
- Cell pole-specific activation of a critical bacterial cell cycle kinase.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Discovery of the autonomously replicating plasmid pMF1 from Myxococcus fulvus and development of a gene cloning system in Myxococcus xanthus.Applied and environmental microbiology · 2008Article
- Bioinformatics and experimental analysis of proteins of two-component systems in Myxococcus xanthus.Journal of bacteriology · 2008Article
- Cohesion-defective mutants of Myxococcus xanthus.Journal of bacteriology · 2006Article
- EspC is involved in controlling the timing of development in Myxococcus xanthus.Journal of bacteriology · 2005Article
- An adenylyl cyclase, CyaB, acts as an osmosensor in Myxococcus xanthus.Journal of bacteriology · 2005Article
- An adenylyl cyclase, CyaA, of Myxococcus xanthus functions in signal transduction during osmotic stress.Journal of bacteriology · 2002Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A gene, mokA, encoding a protein with similarities to histidine kinase-response regulator hybrid sensor, was cloned from a Myxococcus xanthus genomic library. The predicted mokA gene product was found to contain three domains: an amino-terminal input domain, a central transmitter domain, and a carboxy-terminal receiver domain. mokA mutants placed under starvation conditions exhibited reduced sporulation. Mutation of mokA also caused marked growth retardation at high osmolarity. These results indicated that M. xanthus MokA is likely a transmembrane sensor that is required for development and osmotic tolerance. The putative function of MokA is similar to that of the hybrid histidine kinase, DokA, of the eukaryotic slime mold Dictyostelium discoideum.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.