ArticleJournal of bacteriology2001
A novel serotype-specific gene cassette (gltA-gltB) is required for expression of teichoic acid-associated surface antigens in Listeria monocytogenes of serotype 4b.
Article in Journal of bacteriology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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36 citing papers in PubMed, 60 citations in OpenAlex.
- Large-scale phenotyping and comparative genomics reveal genetic features of Listeria persistence in epithelial cells.PLoS pathogens · 2026Article
- Phage P100 resistance in clinical and foodborneCurrent research in microbial sciences · 2026Article
- Dual glycosylation of wall teichoic acid modulates the O-antigen pattern and virulence in serovar 4bmLife · 2025Article
- Hypervirulent clonal complex (CC) ofFrontiers in microbiology · 2024Article
- Whole-Genome Sequence Comparisons ofMicroorganisms · 2022Article
- Whole-Genome Sequencing-Based Characterization of aMicroorganisms · 2021Article
- Environmental dissemination of pathogenic Listeria monocytogenes in flowing surface waters in Switzerland.Scientific reports · 2021Article
- Modifications of cell wall polymers in Gram-positive bacteria by multi-component transmembrane glycosylation systems.Current opinion in microbiology · 2021Review
- Whole Genome Sequence Analysis of Phage-ResistantPathogens (Basel, Switzerland) · 2021Article
- Phylogenetic Analysis and Genome-Wide Association Study Applied to an ItalianFrontiers in microbiology · 2021Article
- Article
- Phage resistance at the cost of virulence: Listeria monocytogenes serovar 4b requires galactosylated teichoic acids for InlB-mediated invasion.PLoS pathogens · 2019Article
- Article
- Molecular detection ofserotype groups ofVeterinary world · 2018Article
- TheFrontiers in microbiology · 2018Article
- CLEC5A is a critical receptor in innate immunity against Listeria infection.Nature communications · 2017Article
- Genome comparison of Listeria monocytogenes serotype 4a strain HCC23 with selected lineage I and lineage II L. monocytogenes strains and other Listeria strains.Genomics data · 2014Article
- The sweet tooth of bacteria: common themes in bacterial glycoconjugates.Microbiology and molecular biology reviews : MMBR · 2014Review
- Article
- Genome-wide identification of ampicillin resistance determinants in Enterococcus faecium.PLoS genetics · 2012Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Listeria monocytogenes serotype 4b strains account for about 40% of sporadic cases and many epidemics of listeriosis. Mutations in a chromosomal locus resulted in loss of reactivity with all three monoclonal antibodies (MAbs) which were specific to serotype 4b and the closely related serotypes 4d and 4e. Here we show that this locus contains a serotype 4b-4d-4e-specific gene cassette (3,071 bp) which consists of two genes, gltA and gltB, and is flanked by palindromic sequences (51 and 44 nucleotides). Complete loss of reactivity with the three serotype-specific MAbs resulted from insertional inactivation of either gltA or gltB. The gltA and gltB mutants were characterized by loss and severe reduction, respectively, of glucose in the teichoic acid, whereas galactose, the other serotype-specific sugar substituent in the teichoic acid, was not affected. Within L. monocytogenes, only strains of serotypes 4b, 4d, and 4e harbored the gltA-gltB cassette, whereas coding sequences on either side of the cassette were conserved among all serotypes. Comparative genomic analysis of a serotype 1/2b strain showed that the 3,071-bp gltA-gltB cassette was replaced by a much shorter (528-bp) and unrelated region, flanked by inverted repeats similar to their counterparts in serotype 4b. These findings indicate that in the evolution of different serotypes of L. monocytogenes, this site in the genome has become occupied by serotype-specific sequences which, in the case of serotype 4b, are essential for expression of serotype-specific surface antigens and presence of glucose substituents in the teichoic acids in the cell wall.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.