ArticleGenes & development2001
The Sir1 protein's association with a silenced chromosome domain.
Article in Genes & development, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 31 citations in OpenAlex.
- The Nuts and Bolts of Transcriptionally Silent Chromatin in Saccharomyces cerevisiae.Genetics · 2016Review
- Ume6 is required for the MATa/MATalpha cellular identity and transcriptional silencing in Kluyveromyces lactis.Genetics · 2010Article
- Expanded roles of the origin recognition complex in the architecture and function of silenced chromatin in Saccharomyces cerevisiae.Molecular and cellular biology · 2010Article
- Elaboration, diversification and regulation of the Sir1 family of silencing proteins in Saccharomyces.Genetics · 2009Article
- Phylogenetic conservation and homology modeling help reveal a novel domain within the budding yeast heterochromatin protein Sir1.Molecular and cellular biology · 2009Article
- A silencer promotes the assembly of silenced chromatin independently of recruitment.Molecular and cellular biology · 2009Article
- Synthetic lethal screens identify gene silencing processes in yeast and implicate the acetylated amino terminus of Sir3 in recognition of the nucleosome core.Molecular and cellular biology · 2008Article
- Conversion of a replication origin to a silencer through a pathway shared by a Forkhead transcription factor and an S phase cyclin.Molecular biology of the cell · 2008Article
- Slx5 promotes transcriptional silencing and is required for robust growth in the absence of Sir2.Molecular and cellular biology · 2008Article
- Epistatic interaction between the K-homology domain protein HEK2 and SIR1 at HMR and telomeres in yeast.Journal of molecular biology · 2008Article
- Tolerance of Sir1p/origin recognition complex-dependent silencing for enhanced origin firing at HMRa.Molecular and cellular biology · 2006Article
- Cell cycle requirements in assembling silent chromatin in Saccharomyces cerevisiae.Molecular and cellular biology · 2006Article
- Structural basis of the Sir1-origin recognition complex interaction in transcriptional silencing.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Molecular requirements for gene expression mediated by targeted histone acetyltransferases.Molecular and cellular biology · 2004Article
- The origin recognition complex and Sir4 protein recruit Sir1p to yeast silent chromatin through independent interactions requiring a common Sir1p domain.Molecular and cellular biology · 2004Article
- The budding yeast silencing protein Sir1 is a functional component of centromeric chromatin.Genes & development · 2003Article
- Differential DNA affinity specifies roles for the origin recognition complex in budding yeast heterochromatin.Genes & development · 2003Article
- Inhibition of polyomavirus ori-dependent DNA replication by mSin3B.Journal of virology · 2002Article
- A unique class of conditional sir2 mutants displays distinct silencing defects in Saccharomyces cerevisiae.Genetics · 2002Article
- Structure and function of the BAH-containing domain of Orc1p in epigenetic silencing.The EMBO journal · 2002Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Silencing of the cryptic mating-type locus HMR requires recognition of a small DNA sequence element, the HMR-E silencer, by the Sir1p, one of four Sir proteins required for the assembly of silenced chromatin domains in Saccharomyces cerevisiae. The Sir1p recognizes the silencer through interactions with the origin recognition complex (ORC), a protein complex that binds the silencer DNA directly. Sir1p was physically associated with HMR in chromatin, and this association required a Sir1p-ORC interaction, suggesting that it reflected the Sir1p silencer-recognition function required for silencing. Sir1p was not associated with nonsilencer replication origins that bind the ORC, indicating that a Sir1p-ORC interaction is confined to silencers. Significantly, the other SIR genes were required for Sir1p's association with HMR. Thus, multiple protein contacts required for and unique to silent chromatin may confine a Sir1p-ORC interaction to silencers. The Sir1p was present at extremely low concentrations in yeast cells yet was associated with HMR at all stages of the cell cycle examined. These data provide insights into the mechanisms that establish and restrict the assembly of silenced chromatin to only a few discrete chromosomal domains.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.