ArticleGenes & development2001
The proteasome regulates the UV-induced activation of the AP-1-like transcription factor Gcn4.
Article in Genes & development, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 32 citations in OpenAlex.
- POH1/Rpn11/PSMD14: a journey from basic research in fission yeast to a prognostic marker and a druggable target in cancer cells.British journal of cancer · 2022Review
- Dysregulation of the Ubiquitin Proteasome System in Human Malignancies: A Window for Therapeutic Intervention.Cancers · 2021Review
- Red Light Modulates Ultraviolet-Induced Gene Expression in the Epidermis of Hairless Mice.Photomedicine and laser surgery · 2015Article
- Article
- Structural defects in the regulatory particle-core particle interface of the proteasome induce a novel proteasome stress response.The Journal of biological chemistry · 2011Article
- The 19S proteasomal lid subunit POH1 enhances the transcriptional activation by Mitf in osteoclasts.Journal of cellular biochemistry · 2010Article
- Gcn4p and novel upstream activating sequences regulate targets of the unfolded protein response.PLoS biology · 2004Article
- Participation of the proteasomal lid subunit Rpn11 in mitochondrial morphology and function is mapped to a distinct C-terminal domain.The Biochemical journal · 2004Article
- Use of RNA interference and complementation to study the function of the Drosophila and human 26S proteasome subunit S13.Molecular and cellular biology · 2003Article
- MPN+, a putative catalytic motif found in a subset of MPN domain proteins from eukaryotes and prokaryotes, is critical for Rpn11 function.BMC biochemistry · 2002Article
- Gcn4p, a master regulator of gene expression, is controlled at multiple levels by diverse signals of starvation and stress.Eukaryotic cell · 2002Review
- Regulation of repair by the 26S proteasome.Journal of biomedicine & biotechnology · 2002Article
- Pathways of retinoic acid- or arsenic trioxide-induced PML/RARalpha catabolism, role of oncogene degradation in disease remission.Oncogene · 2001Review
- The 19S complex of the proteasome regulates nucleotide excision repair in yeast.Genes & development · 2001Article
- Redox control of AP-1-like factors in yeast and beyond.Oncogene · 2001Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
The proteasome is well known for its regulation of the cell cycle and degradation of mis-folded proteins, yet many of its functions are still unknown. We show that RPN11, a gene encoding a subunit of the regulatory cap of the proteasome, is required for UV-stimulated activation of Gcn4p target genes, but is dispensable for their activation by the general control pathway. We provide evidence that RPN11 functions downstream of RAS2, and show that mutation of two additional proteasome subunits results in identical phenotypes. Our analysis defines a novel function of the proteasome: regulation of the RAS- and AP-1 transcription factor-dependent UV resistance pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.