ArticleThe EMBO journal2001
FTZ-Factor1 and Fushi tarazu interact via conserved nuclear receptor and coactivator motifs.
Article in The EMBO journal, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 59 citations in OpenAlex.
- Interaction patterns of methoprene-tolerant and germ cell-expressedFrontiers in molecular biosciences · 2023Article
- Orphan nuclear receptor ftz-f1 (NR5A3) promotes egg chamber survival in the Drosophila ovary.G3 (Bethesda, Md.) · 2021Article
- Hox genes, evo-devo, and the case of the ftz gene.Chromosoma · 2016Review
- Article
- Spatial profiling of nuclear receptor transcription patterns over the course of Drosophila development.G3 (Bethesda, Md.) · 2013Article
- Variation and constraint in Hox gene evolution.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- The Drosophila juvenile hormone receptor candidates methoprene-tolerant (MET) and germ cell-expressed (GCE) utilize a conserved LIXXL motif to bind the FTZ-F1 nuclear receptor.The Journal of biological chemistry · 2012Article
- Crystal structure of Fushi tarazu factor 1 ligand binding domain/Fushi tarazu peptide complex identifies new class of nuclear receptors.The Journal of biological chemistry · 2011Article
- CrkL is a co-activator of estrogen receptor alpha that enhances tumorigenic potential in cancer.Molecular endocrinology (Baltimore, Md.) · 2011Article
- Lack of the Drosophila BEAF insulator proteins alters regulation of genes in the Antennapedia complex.Molecular genetics and genomics : MGG · 2011Article
- Surprising flexibility in a conserved Hox transcription factor over 550 million years of evolution.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Directionality of nucleocytoplasmic transport of the retroviral gag protein depends on sequential binding of karyopherins and viral RNA.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Context-dependent regulation of Hox protein functions by CK2 phosphorylation sites.Development genes and evolution · 2008Article
- A genetic screen supports a broad role for the Drosophila insulator proteins BEAF-32A and BEAF-32B in maintaining patterns of gene expression.Molecular genetics and genomics : MGG · 2007Article
- Abeta induces cell death by direct interaction with its cognate extracellular domain on APP (APP 597-624).FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2006Article
- A screen for genes that interact with the Drosophila pair-rule segmentation gene fushi tarazu.Genetics · 2004Article
- Functional conservation of interactions between a homeodomain cofactor and a mammalian FTZ-F1 homologue.EMBO reports · 2004Article
- Prox1 is a novel coregulator of Ff1b and is involved in the embryonic development of the zebra fish interrenal primordium.Molecular and cellular biology · 2003Article
- LXXLL-related motifs in Dax-1 have target specificity for the orphan nuclear receptors Ad4BP/SF-1 and LRH-1.Molecular and cellular biology · 2003Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To activate transcription, most nuclear receptor proteins require coactivators that bind to their ligand-binding domains (LBDs). The Drosophila FTZ-Factor1 (FTZ-F1) protein is a conserved member of the nuclear receptor superfamily, but was previously thought to lack an AF2 motif, a motif that is required for ligand and coactivator binding. Here we show that FTZ-F1 does have an AF2 motif and that it is required to bind a coactivator, the homeodomain-containing protein Fushi tarazu (FTZ). We also show that FTZ contains an AF2-interacting nuclear receptor box, the first to be found in a homeodomain protein. Both interaction motifs are shown to be necessary for physical interactions in vitro and for functional interactions in developing embryos. These unexpected findings have important implications for the conserved homologs of the two proteins.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.