ArticleApplied and environmental microbiology2001
Naturally occurring lactococcal plasmid pAH90 links bacteriophage resistance and mobility functions to a food-grade selectable marker.
Article in Applied and environmental microbiology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22 citing papers in PubMed, 56 citations in OpenAlex.
- Plant growth-promoting and heavy metal-resistant Priestia and Bacillus strains associated with pioneer plants from mine tailings.Archives of microbiology · 2023Article
- Large plasmidome of dairy Lactococcus lactis subsp. lactis biovar diacetylactis FM03P encodes technological functions and appears highly unstable.BMC genomics · 2018Article
- Identification of key proteins and pathways in cadmium tolerance of Lactobacillus plantarum strains by proteomic analysis.Scientific reports · 2017Article
- Plasmids from Food Lactic Acid Bacteria: Diversity, Similarity, and New Developments.International journal of molecular sciences · 2015Review
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- In vivo and ex vivo evaluations of bacteriophages e11/2 and e4/1c for use in the control of Escherichia coli O157:H7.Applied and environmental microbiology · 2010Article
- Roseophage RDJL Phi1, infecting the aerobic anoxygenic phototrophic bacterium Roseobacter denitrificans OCh114.Applied and environmental microbiology · 2009Article
- A kinetic study on the plasmid stability of three Lactococcus lactis strains.Journal of industrial microbiology & biotechnology · 2007Article
- Trans-splicing of the Ll.LtrB group II intron in Lactococcus lactis.Nucleic acids research · 2007Article
- Restriction for gene insertion within the Lactococcus lactis Ll.LtrB group II intron.RNA (New York, N.Y.) · 2006Article
- Sequence analysis of the lactococcal plasmid pNP40: a mobile replicon for coping with environmental hazards.Journal of bacteriology · 2006Article
- Horizontal gene transfer of PIB-type ATPases among bacteria isolated from radionuclide- and metal-contaminated subsurface soils.Applied and environmental microbiology · 2006Article
- Glutamate dehydrogenase activity can be transmitted naturally to Lactococcus lactis strains to stimulate amino acid conversion to aroma compounds.Applied and environmental microbiology · 2006Article
- Complete sequences of four plasmids of Lactococcus lactis subsp. cremoris SK11 reveal extensive adaptation to the dairy environment.Applied and environmental microbiology · 2005Article
- Insertional inactivation of determinants for Mg2+ and Co2+ transport as a tool for screening recombinant Lactococcus species clones.Applied and environmental microbiology · 2005Article
- The gene encoding the glutamate dehydrogenase in Lactococcus lactis is part of a remnant Tn3 transposon carried by a large plasmid.Journal of bacteriology · 2005Article
- Quantitative analysis of group II intron expression and splicing in Lactococcus lactis.Applied and environmental microbiology · 2005Article
- Conjugative transfer of the Lactococcus lactis chromosomal sex factor promotes dissemination of the Ll.LtrB group II intron.Journal of bacteriology · 2005Article
- Conserved target for group II intron insertion in relaxase genes of conjugative elements of gram-positive bacteria.Journal of bacteriology · 2004Article
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6 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
The bacteriophage resistance plasmid pAH90 (26,490 bp) is a natural cointegrate plasmid formed via homologous recombination between the type I restriction-modification specificity determinants (hsdS) of two smaller lactococcal plasmids, pAH33 (6,159 bp) and pAH82 (20,331 bp), giving rise to a bacteriophage-insensitive mutant following phage challenge (D. O'Sullivan, D. P. Twomey, A. Coffey, C. Hill, G. F. Fitzgerald, and R. P. Ross, Mol. Microbiol. 36:866-876; 2000). In this communication we provide evidence that the recombination event is favored by phage infection. The entire nucleotide sequence of plasmid pAH90 was determined and found to contain 24 open reading frames (ORFs) responsible for phenotypes which include restriction-modification, phage adsorption inhibition, plasmid replication, cadmium resistance, cobalt transport, and conjugative mobilization. The cadmium resistance property, encoded by the cadA gene, which has an associated regulatory gene (cadC), is of particular interest, as it facilitated the selection of pAH90 in other phage-sensitive lactococci after electroporation. In addition, we report the identification of a group II self-splicing intron bounded by two exons which have the capacity to encode a relaxase implicated in conjugation in gram-positive bacteria. The functionality of this intron was evident by demonstrating splicing in vivo. Given that pAH90 encodes potent phage defense systems which act at different stages in the phage lytic cycle, the linkage of these with a food-grade selectable marker on a replicon that can be mobilized among lactococci has significant potential for natural strain improvement for industrial dairy fermentations which are susceptible to phage inhibition.
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